TY - JOUR
T1 - Caloric restriction modifies both innate and adaptive immunity in the mouse small intestine
AU - Suárez-Souto, María Antonieta
AU - Lara-Padilla, Eleazar
AU - Reyna-Garfias, Humberto
AU - Viloria, María
AU - López-Sánchez, Pedro
AU - Rivera-Aguilar, Víctor
AU - Miliar-García, Ángel
AU - Kormanovski, Alexander
AU - Domínguez-López, María Lilia
AU - Campos-Rodríguez, Rafael
N1 - Funding Information:
We thank Bruce Allan Larsen for reviewing the use of English in this manuscript. This work was supported in part by grants from SEPI-IPN. Suarez-Souto MA and Maria Viloria received a scholarship from Conacyt, México. Dominguez Lopez ML, Campos-Rodriguez R, Miliar-Garcia A are fellows of COFAA and SIP-IPN. None of the authors has any conflict of interest in relation to the subjects mentioned or techniques utilized in this manuscript.
PY - 2012/6
Y1 - 2012/6
N2 - Although caloric restriction (CR) apparently has beneficial effects on the immune system, its effects on the immunological function of the intestinal mucosa are little known. The present study explored the effect of CR on the innate and adaptive intestinal immunity of mice. Balb/c mice were either fed ad libitum (control) or on alternate days fed ad libitum and fasted (caloric restriction). After 4 months, an evaluation was made of IgA levels in the ileum, the gene expression for IgA and its receptor (pIgR), as well as the expression of two antimicrobial enzymes (lysozyme and phospholipase A2) and several cytokines of the intestinal mucosa. CR increased the gene expression of lysozyme and phospholipase A2. The levels of IgA were diminished in the ileum, which apparently was a consequence of the reduced transport of IgA by pIgR. In ileum, CR increased the gene expression for most cytokines, both pro- and antiinflammatory. Hence, CR differentially modified the expression of innate and adaptive immunity mediators in the intestine.
AB - Although caloric restriction (CR) apparently has beneficial effects on the immune system, its effects on the immunological function of the intestinal mucosa are little known. The present study explored the effect of CR on the innate and adaptive intestinal immunity of mice. Balb/c mice were either fed ad libitum (control) or on alternate days fed ad libitum and fasted (caloric restriction). After 4 months, an evaluation was made of IgA levels in the ileum, the gene expression for IgA and its receptor (pIgR), as well as the expression of two antimicrobial enzymes (lysozyme and phospholipase A2) and several cytokines of the intestinal mucosa. CR increased the gene expression of lysozyme and phospholipase A2. The levels of IgA were diminished in the ileum, which apparently was a consequence of the reduced transport of IgA by pIgR. In ileum, CR increased the gene expression for most cytokines, both pro- and antiinflammatory. Hence, CR differentially modified the expression of innate and adaptive immunity mediators in the intestine.
KW - Caloric restriction
KW - Cytokines
KW - IgA
KW - Intestinal immunity
KW - Lysozyme
KW - Phospholipase A
UR - http://www.scopus.com/inward/record.url?scp=84864029670&partnerID=8YFLogxK
U2 - 10.1007/s13105-011-0128-9
DO - 10.1007/s13105-011-0128-9
M3 - Artículo
C2 - 22086353
SN - 1138-7548
VL - 68
SP - 163
EP - 173
JO - Journal of Physiology and Biochemistry
JF - Journal of Physiology and Biochemistry
IS - 2
ER -