Caloric restriction modifies both innate and adaptive immunity in the mouse small intestine

María Antonieta Suárez-Souto, Eleazar Lara-Padilla, Humberto Reyna-Garfias, María Viloria, Pedro López-Sánchez, Víctor Rivera-Aguilar, Ángel Miliar-García, Alexander Kormanovski, María Lilia Domínguez-López, Rafael Campos-Rodríguez

Research output: Contribution to journalArticle

10 Scopus citations


Although caloric restriction (CR) apparently has beneficial effects on the immune system, its effects on the immunological function of the intestinal mucosa are little known. The present study explored the effect of CR on the innate and adaptive intestinal immunity of mice. Balb/c mice were either fed ad libitum (control) or on alternate days fed ad libitum and fasted (caloric restriction). After 4 months, an evaluation was made of IgA levels in the ileum, the gene expression for IgA and its receptor (pIgR), as well as the expression of two antimicrobial enzymes (lysozyme and phospholipase A2) and several cytokines of the intestinal mucosa. CR increased the gene expression of lysozyme and phospholipase A2. The levels of IgA were diminished in the ileum, which apparently was a consequence of the reduced transport of IgA by pIgR. In ileum, CR increased the gene expression for most cytokines, both pro- and antiinflammatory. Hence, CR differentially modified the expression of innate and adaptive immunity mediators in the intestine. © 2011 University of Navarra.
Original languageAmerican English
Pages (from-to)163-173
Number of pages145
JournalJournal of Physiology and Biochemistry
StatePublished - 1 Jun 2012


Cite this