TY - JOUR
T1 - C-Phycocyanin prevents acute myocardial infarction-induced oxidative stress, inflammation and cardiac damage
AU - Blas-Valdivia, Vanessa
AU - Moran-Dorantes, Daniela Nikita
AU - Rojas-Franco, Placido
AU - Franco-Colin, Margarita
AU - Mirhosseini, Neda
AU - Davarnejad, Reza
AU - Halajisani, Ahmad
AU - Tavakoli, Omid
AU - Cano-Europa, Edgar
N1 - Publisher Copyright:
© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - Context: C-Phycocyanin is a protein with anti-scavenger, antioxidant and anti-inflammatory actions against agents that cause cellular damage. The cardioprotective action of C-phycocyanin against acute myocardial infarction (AMI) has not been studied in animal models. Objective: To investigate C-phycocyanin’s effect on oxidative stress, inflammation and cardiac damage in a model of isoproterenol-induced AMI. Materials and methods: Wistar rats were divided into four groups: (1) sham + vehicle (0.9% saline solution by oral gavage, OG); (2) sham + C-phycocyanin (50 mg/kg/d, OG); (3) AMI + vehicle, and (4) AMI + C-phycocyanin. AMI was induced by administering isoproterenol (20, 10, 5 and 3 mg/kg each dose per day), and serum cardiac enzymes were quantified. After five days, the animals were euthanized; the heart was dissected to determine oxidative stress, redox environment, inflammation and cardiac damage markers. Results: We observed that C-phycocyanin reduced AMI-increased cardiac enzymes (CK by about 53%, CKMB by about 60%, AST by about 16% and ALT by about 21%), lipid peroxidation (57%), reactive oxygen species (50%), nitrites (46%), oxidized glutathione (41%), IL1β (3%), INFγ (5%), TNFα 3%), Bcl2 (37%), Bax (43%), COX2 (21%) and caspase 9 (61%). Finally, C-phycocyanin reduced AMI-induced aberrant histological changes related to myonecrosis, interstitial oedema and inflammatory infiltration in the heart muscle. Conclusions: C-Phycocyanin prevents AMI-induced oxidative stress, inflammation and heart damage. This study is the first report that employed C-phycocyanin in an animal model of AMI and supports the potential use of C-phycocyanin in the management of AMI.
AB - Context: C-Phycocyanin is a protein with anti-scavenger, antioxidant and anti-inflammatory actions against agents that cause cellular damage. The cardioprotective action of C-phycocyanin against acute myocardial infarction (AMI) has not been studied in animal models. Objective: To investigate C-phycocyanin’s effect on oxidative stress, inflammation and cardiac damage in a model of isoproterenol-induced AMI. Materials and methods: Wistar rats were divided into four groups: (1) sham + vehicle (0.9% saline solution by oral gavage, OG); (2) sham + C-phycocyanin (50 mg/kg/d, OG); (3) AMI + vehicle, and (4) AMI + C-phycocyanin. AMI was induced by administering isoproterenol (20, 10, 5 and 3 mg/kg each dose per day), and serum cardiac enzymes were quantified. After five days, the animals were euthanized; the heart was dissected to determine oxidative stress, redox environment, inflammation and cardiac damage markers. Results: We observed that C-phycocyanin reduced AMI-increased cardiac enzymes (CK by about 53%, CKMB by about 60%, AST by about 16% and ALT by about 21%), lipid peroxidation (57%), reactive oxygen species (50%), nitrites (46%), oxidized glutathione (41%), IL1β (3%), INFγ (5%), TNFα 3%), Bcl2 (37%), Bax (43%), COX2 (21%) and caspase 9 (61%). Finally, C-phycocyanin reduced AMI-induced aberrant histological changes related to myonecrosis, interstitial oedema and inflammatory infiltration in the heart muscle. Conclusions: C-Phycocyanin prevents AMI-induced oxidative stress, inflammation and heart damage. This study is the first report that employed C-phycocyanin in an animal model of AMI and supports the potential use of C-phycocyanin in the management of AMI.
KW - Phycobiliproteins
KW - anti-inflammatory
KW - cardioprotection
KW - cardiotoxicity
KW - heart damage
UR - http://www.scopus.com/inward/record.url?scp=85127502934&partnerID=8YFLogxK
U2 - 10.1080/13880209.2022.2055089
DO - 10.1080/13880209.2022.2055089
M3 - Artículo
C2 - 35373708
AN - SCOPUS:85127502934
SN - 1388-0209
VL - 60
SP - 755
EP - 763
JO - Pharmaceutical Biology
JF - Pharmaceutical Biology
IS - 1
ER -