TY - JOUR
T1 - Boron-containing compounds on neurons
T2 - Actions and potential applications for treating neurodegenerative diseases
AU - Barrón-González, Mónica
AU - Montes-Aparicio, Alexia V.
AU - Cuevas-Galindo, M. Emilio
AU - Orozco-Suárez, Sandra
AU - Barrientos, Rafael
AU - Alatorre, Alberto
AU - Querejeta, Enrique
AU - Trujillo-Ferrara, José G.
AU - Farfán-García, Eunice D.
AU - Soriano-Ursúa, Marvin A.
N1 - Publisher Copyright:
© 2022
PY - 2023/1
Y1 - 2023/1
N2 - Boron-containing compounds (BCC) exert effects on neurons. After the expanding of both the identification and synthesis of new BCC, novel effects in living systems have been reported, many of these involving neuronal action. In this review, the actions of BCC on neurons are described; the effects have been inferred by boron deprivation or addition. Also, the effects can be related to those mediated by interaction on ionic channels, G-protein coupled receptors, or other receptors exerting modification on neuronal behavior. Additionally, BCC have exhibited effects by the modulation of inflammation or oxidative processes. BCC are expanding as drugs. Deprivation of boron sources from the diet shows the role of some natural BCC. However, the observations of several new synthesized compounds suggest their ability to act with attractive potency, efficacy, and long-term action on neuronal receptors or processes related with the origin and evolution of neurodegenerative processes. The details of BCC-target interactions are currently being elucidated in progress, as those observed from BCC-protein crystal complexes. Taking all of the above into account, the expansion is presumably near to having studies on the application of BCC as drugs on specific targets for treating neurodegenerative diseases.
AB - Boron-containing compounds (BCC) exert effects on neurons. After the expanding of both the identification and synthesis of new BCC, novel effects in living systems have been reported, many of these involving neuronal action. In this review, the actions of BCC on neurons are described; the effects have been inferred by boron deprivation or addition. Also, the effects can be related to those mediated by interaction on ionic channels, G-protein coupled receptors, or other receptors exerting modification on neuronal behavior. Additionally, BCC have exhibited effects by the modulation of inflammation or oxidative processes. BCC are expanding as drugs. Deprivation of boron sources from the diet shows the role of some natural BCC. However, the observations of several new synthesized compounds suggest their ability to act with attractive potency, efficacy, and long-term action on neuronal receptors or processes related with the origin and evolution of neurodegenerative processes. The details of BCC-target interactions are currently being elucidated in progress, as those observed from BCC-protein crystal complexes. Taking all of the above into account, the expansion is presumably near to having studies on the application of BCC as drugs on specific targets for treating neurodegenerative diseases.
KW - Boron
KW - Boron-containing compounds
KW - Neurodegeneration
KW - Neuroinflammation
KW - Neurons
KW - Organoboron compounds
UR - http://www.scopus.com/inward/record.url?scp=85142939863&partnerID=8YFLogxK
U2 - 10.1016/j.jinorgbio.2022.112027
DO - 10.1016/j.jinorgbio.2022.112027
M3 - Artículo de revisión
C2 - 36345068
AN - SCOPUS:85142939863
SN - 0162-0134
VL - 238
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
M1 - 112027
ER -