TY - JOUR
T1 - Biomarkers of Cytotoxic, Genotoxic and Apoptotic Effects in Cyprinus carpio Exposed to Complex Mixture of Contaminants from Hospital Effluents
AU - Olvera-Néstor, Corina G.
AU - Morales-Avila, Enrique
AU - Gómez-Olivan, Leobardo M.
AU - Galár-Martínez, Marcela
AU - García-Medina, Sandra
AU - Neri-Cruz, Nadia
N1 - Publisher Copyright:
© 2016 Springer Science+Business Media.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Hospital wastewater is an important source of emerging contaminants. Recent studies emphasize the importance of assessing the effects of mixtures of contaminants rather than environmental risk of their individual components, as well as the determination of intrinsic toxicity of wastewater. Mixtures of pollutants has possible interactions that have notable environmental side effects. The aim of this study is an attempt to characterize biomarkers in Cyprinus carpio related to the exposure to a complex mixture of contaminants found in hospital wastewater. Results of a particular hospital effluent show the presence of traces of heavy metals, high chlorine concentration and emerging contaminants such as non-steroidal anti-inflammatory drugs. The LC50 was of 5.49 % at 96 h. The cytotoxic, genotoxic and apoptotic biomarkers increase when fishes were exposed to wastewater (1/10 CL50) from hospital wastewater. This study emphasizes the importance of identifying and quantifying the effects of contaminants as pharmaceuticals, disinfectants and surfactants in order to design and implement an ecotoxicologycal plan.
AB - Hospital wastewater is an important source of emerging contaminants. Recent studies emphasize the importance of assessing the effects of mixtures of contaminants rather than environmental risk of their individual components, as well as the determination of intrinsic toxicity of wastewater. Mixtures of pollutants has possible interactions that have notable environmental side effects. The aim of this study is an attempt to characterize biomarkers in Cyprinus carpio related to the exposure to a complex mixture of contaminants found in hospital wastewater. Results of a particular hospital effluent show the presence of traces of heavy metals, high chlorine concentration and emerging contaminants such as non-steroidal anti-inflammatory drugs. The LC50 was of 5.49 % at 96 h. The cytotoxic, genotoxic and apoptotic biomarkers increase when fishes were exposed to wastewater (1/10 CL50) from hospital wastewater. This study emphasizes the importance of identifying and quantifying the effects of contaminants as pharmaceuticals, disinfectants and surfactants in order to design and implement an ecotoxicologycal plan.
KW - Biomarkers
KW - Cytotoxicity
KW - Emergent contaminants
KW - Genotoxicity
KW - Hospital effluents
UR - http://www.scopus.com/inward/record.url?scp=84959573755&partnerID=8YFLogxK
U2 - 10.1007/s00128-015-1721-3
DO - 10.1007/s00128-015-1721-3
M3 - Artículo
SN - 0007-4861
VL - 96
SP - 326
EP - 332
JO - Bulletin of Environmental Contamination and Toxicology
JF - Bulletin of Environmental Contamination and Toxicology
IS - 3
ER -