TY - JOUR
T1 - Beneficial Effects of Fructooligosaccharides Esterified with Lauric Acid in a Metabolic Syndrome Model Induced by a High-Fat and High-Carbohydrate Diet in Wistar Rats
AU - Hernández-Pérez, Susana
AU - Oliart-Ros, Rosa María
AU - Casas-Godoy, Leticia
AU - Sandoval, Georgina
AU - Guarner-Lans, Verónica
AU - Castrejón-Téllez, Vicente
AU - Quevedo-Corona, Lucía
AU - Peña-Montes, Carolina
AU - Ramírez-Higuera, Abril
N1 - Publisher Copyright:
© 2022, Mary Ann Liebert, Inc., publishers, and Korean Society of Food Science and Nutrition 2022.
PY - 2022/8/1
Y1 - 2022/8/1
N2 - Metabolic syndrome (MS) is a group of abnormalities in which obesity, insulin resistance (IR), oxidative stress, and dyslipidemia stand out. This pathology predisposes to the development of cardiovascular diseases and diabetes. The ingestion of linear fructooligosaccharides (FOS) such as inulin reduces conditions such as hyperinsulinemia, increased body fat, and triglyceridemia. When FOS are esterified with fatty acids, they present emulsifying and surfactant properties; however, there are no reports of their function at the biological level. The purpose of this investigation was to evaluate the effect of Agave tequilana Weber's FOS (AtW-FOS) and FOS esterified with lauric acid (FOS-LA) in MS markers in a rat model induced by a HFHC diet. Supplementation with AtW-FOS and FOS-LA decreased IR, improved glucose tolerance, reduced liver weight (19%), plasma triglycerides (24%), and blood pressure (16%) when compared with the untreated MS group. In conclusion, the ingestion of AtW-FOS and FOS-LA has beneficial effects in the prevention of MS alterations, showing a high potential for their application in functional foods.
AB - Metabolic syndrome (MS) is a group of abnormalities in which obesity, insulin resistance (IR), oxidative stress, and dyslipidemia stand out. This pathology predisposes to the development of cardiovascular diseases and diabetes. The ingestion of linear fructooligosaccharides (FOS) such as inulin reduces conditions such as hyperinsulinemia, increased body fat, and triglyceridemia. When FOS are esterified with fatty acids, they present emulsifying and surfactant properties; however, there are no reports of their function at the biological level. The purpose of this investigation was to evaluate the effect of Agave tequilana Weber's FOS (AtW-FOS) and FOS esterified with lauric acid (FOS-LA) in MS markers in a rat model induced by a HFHC diet. Supplementation with AtW-FOS and FOS-LA decreased IR, improved glucose tolerance, reduced liver weight (19%), plasma triglycerides (24%), and blood pressure (16%) when compared with the untreated MS group. In conclusion, the ingestion of AtW-FOS and FOS-LA has beneficial effects in the prevention of MS alterations, showing a high potential for their application in functional foods.
KW - Agave
KW - Fructooligosaccharides
KW - High-fat high-carbohydrate diet
KW - Lauric acid
KW - Prebiotics
UR - http://www.scopus.com/inward/record.url?scp=85134260126&partnerID=8YFLogxK
U2 - 10.1089/jmf.2021.0109
DO - 10.1089/jmf.2021.0109
M3 - Artículo
C2 - 35394894
AN - SCOPUS:85134260126
SN - 1096-620X
VL - 25
SP - 828
EP - 835
JO - Journal of Medicinal Food
JF - Journal of Medicinal Food
IS - 8
ER -