TY - JOUR
T1 - Beneficial Effects of Flavonoids on Skeletal Muscle Health
T2 - A Systematic Review and Meta-Analysis
AU - Munguía, Levy
AU - Ortiz Flores, Miguel Ángel
AU - González, Cristian
AU - Portilla, Andrés
AU - Meaney, Eduardo
AU - Villarreal, Francisco
AU - Nájera, Nayelli
AU - Ceballos, Guillermo
N1 - Publisher Copyright:
Copyright © 2022, Mary Ann Liebert, Inc.
PY - 2022/5
Y1 - 2022/5
N2 - Skeletal muscle (SkM) is a highly dynamic tissue that responds to physiological adaptations or pathological conditions, and SkM mitochondria play a major role in bioenergetics, regulation of intracellular calcium homeostasis, pro-oxidant/antioxidant balance, and apoptosis. Flavonoids are polyphenolic compounds with the ability to modulate molecular pathways implicated in the development of mitochondrial myopathy. Therefore, it is pertinent to explore its potential application in conditions such as aging, disuse, denervation, diabetes, obesity, and cancer. To evaluate preclinical and clinical effects of flavonoids on SkM structure and function. We performed a systematic review of published studies, with no date restrictions applied, using PubMed and Scopus. The following search terms were used: "flavonoids"OR "flavanols"OR "flavones"OR "anthocyanidins"OR "flavanones"OR "flavan-3-ols"OR "catechins"OR "epicatechin"OR "(-)-epicatechin"AND "skeletal muscle."The studies included in this review were preclinical studies, clinical trials, controlled clinical trials, and randomized-controlled trials that investigated the influence of flavonoids on SkM health. Three authors, independently, assessed trials for the review. Any disagreement was resolved by consensus. The use of flavonoids could be a potential tool for the prevention of muscle loss. Their effects on metabolism and on mitochondria function suggest their use as muscle regulators.
AB - Skeletal muscle (SkM) is a highly dynamic tissue that responds to physiological adaptations or pathological conditions, and SkM mitochondria play a major role in bioenergetics, regulation of intracellular calcium homeostasis, pro-oxidant/antioxidant balance, and apoptosis. Flavonoids are polyphenolic compounds with the ability to modulate molecular pathways implicated in the development of mitochondrial myopathy. Therefore, it is pertinent to explore its potential application in conditions such as aging, disuse, denervation, diabetes, obesity, and cancer. To evaluate preclinical and clinical effects of flavonoids on SkM structure and function. We performed a systematic review of published studies, with no date restrictions applied, using PubMed and Scopus. The following search terms were used: "flavonoids"OR "flavanols"OR "flavones"OR "anthocyanidins"OR "flavanones"OR "flavan-3-ols"OR "catechins"OR "epicatechin"OR "(-)-epicatechin"AND "skeletal muscle."The studies included in this review were preclinical studies, clinical trials, controlled clinical trials, and randomized-controlled trials that investigated the influence of flavonoids on SkM health. Three authors, independently, assessed trials for the review. Any disagreement was resolved by consensus. The use of flavonoids could be a potential tool for the prevention of muscle loss. Their effects on metabolism and on mitochondria function suggest their use as muscle regulators.
KW - flavonoids
KW - polyphenols
KW - skeletal muscle
UR - http://www.scopus.com/inward/record.url?scp=85130500375&partnerID=8YFLogxK
U2 - 10.1089/jmf.2021.0054
DO - 10.1089/jmf.2021.0054
M3 - Artículo de revisión
C2 - 35394826
AN - SCOPUS:85130500375
SN - 1096-620X
VL - 25
SP - 465
EP - 486
JO - Journal of Medicinal Food
JF - Journal of Medicinal Food
IS - 5
ER -