TY - JOUR
T1 - Association of the rs1801133 variant in the MTHFR gene and sporadic Parkinson's disease
AU - García, Silvia
AU - Coral-Vázquez, Ramón Mauricio
AU - Gallegos-Arreola, Martha P.
AU - Montes-Almanza, Luis Ángel
AU - Canto, Patricia
AU - García-Martínez, Froylan Arturo
AU - Chavira-Hernández, Gerardo
AU - Palma-Flores, Carlos
AU - Dávila-Maldonado, Luis
AU - Cuevas-García, Carlos F.
AU - Hernández, Luz Berenice López
PY - 2015
Y1 - 2015
N2 - The MTHFR gene has been reported as a susceptibility locus for sporadic Parkinson's disease (sPD). The functional variant rs1801133 has been linked to hyperhomocysteinemia and dopaminergic cell death. Among different populations, Mexican-Mestizos (most present-day Mexicans) have the highest frequency of this variant. Therefore, we sought to determine a possible association of rs1801133 with SPD. In total, 356 individuals were included: 140 pa tients with PD, diagnosed according to the Queen Square Brain Bank criteria, and 216 neurologically healthy controls. Genotyping was performed using TaqMan probes for rs1801133 and real-time PCR. Logistic regression analysis with adjustment for smoking and gender was used to test for an association between genotype and SPD. The CC genotype was associated with SPD; exp(β) = 2.06; 95% CI: 1.101-3.873, p = 0.024. No association with age at onset, cognitive impairment or gender was found in our study group. Our data suggest an important role of MTHFR gene variants in SPD.
AB - The MTHFR gene has been reported as a susceptibility locus for sporadic Parkinson's disease (sPD). The functional variant rs1801133 has been linked to hyperhomocysteinemia and dopaminergic cell death. Among different populations, Mexican-Mestizos (most present-day Mexicans) have the highest frequency of this variant. Therefore, we sought to determine a possible association of rs1801133 with SPD. In total, 356 individuals were included: 140 pa tients with PD, diagnosed according to the Queen Square Brain Bank criteria, and 216 neurologically healthy controls. Genotyping was performed using TaqMan probes for rs1801133 and real-time PCR. Logistic regression analysis with adjustment for smoking and gender was used to test for an association between genotype and SPD. The CC genotype was associated with SPD; exp(β) = 2.06; 95% CI: 1.101-3.873, p = 0.024. No association with age at onset, cognitive impairment or gender was found in our study group. Our data suggest an important role of MTHFR gene variants in SPD.
KW - C677T
KW - Common variants
KW - MTHFR
KW - Mexico
KW - Parkinson's disease
KW - Rs1801133
UR - http://www.scopus.com/inward/record.url?scp=84925800706&partnerID=8YFLogxK
U2 - 10.5114/fn.2015.49971
DO - 10.5114/fn.2015.49971
M3 - Artículo
SN - 1641-4640
VL - 53
SP - 24
EP - 28
JO - Folia Neuropathologica
JF - Folia Neuropathologica
IS - 1
ER -