Association of the rs1801133 variant in the MTHFR gene and sporadic Parkinson's disease

Silvia García, Ramón Mauricio Coral-Vázquez, Martha P. Gallegos-Arreola, Luis Ángel Montes-Almanza, Patricia Canto, Froylan Arturo García-Martínez, Gerardo Chavira-Hernández, Carlos Palma-Flores, Luis Dávila-Maldonado, Carlos F. Cuevas-García, Luz Berenice López Hernández

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The MTHFR gene has been reported as a susceptibility locus for sporadic Parkinson's disease (sPD). The functional variant rs1801133 has been linked to hyperhomocysteinemia and dopaminergic cell death. Among different populations, Mexican-Mestizos (most present-day Mexicans) have the highest frequency of this variant. Therefore, we sought to determine a possible association of rs1801133 with SPD. In total, 356 individuals were included: 140 pa tients with PD, diagnosed according to the Queen Square Brain Bank criteria, and 216 neurologically healthy controls. Genotyping was performed using TaqMan probes for rs1801133 and real-time PCR. Logistic regression analysis with adjustment for smoking and gender was used to test for an association between genotype and SPD. The CC genotype was associated with SPD; exp(β) = 2.06; 95% CI: 1.101-3.873, p = 0.024. No association with age at onset, cognitive impairment or gender was found in our study group. Our data suggest an important role of MTHFR gene variants in SPD.

Original languageEnglish
Pages (from-to)24-28
Number of pages5
JournalFolia Neuropathologica
Volume53
Issue number1
DOIs
StatePublished - 2015

Keywords

  • C677T
  • Common variants
  • MTHFR
  • Mexico
  • Parkinson's disease
  • Rs1801133

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