Association of the polymorphisms 292C>T and 1304G>A in the SLC38A4 gene with hyperglycaemia

Siblie Marbey González-Renteria, Verónica Loera-Castañeda, Isaías Chairez-Hernández, Martha Sosa-Macias, Norma Paniagua-Castro, Ismael Lares-Aseff, Martha Rodríguez-Moran, Fernando Guerrero-Romero, Carlos Galaviz-Hernández

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Abstract

The SLC38A4 gene is related to system 'A' activity, which seems to be related to impaired gluconeogenesis. The objective of this study was to determine whether the 292C>T and 1304G>A polymorphisms of SLC38A4 gene are associated with hyperglycaemia in humans. Methods: A total of 227 individuals were enrolled in a case-control study, in which hyperglycaemia was defined by plasma glucose levels ≥95mg/dL. Genotyping was carried out by using real-time polymerase chain reaction. Results: The frequency of mutant alleles of SLC38A4 gene for single-nucleotide polymorphism (SNP) 1304G>A was 23.6% and 30.2% for SNP 292C>T. The frequency of allele T for the SNP 292C>T in the case and control groups did not show significant differences, whereas the frequency of allele A for the SNP 1304G>A was significantly higher in the case group than in the control group (p=0.04). In the logistic regression analysis, the SNP 1304G>A [odds ratio (OR) 1.78; 95%CI 1.04-3.05, p=0.03] but not SNP 292C>T (OR 1.41; 95%CI 0.80-2.47, p=0.23) showed a significant association with hyperglycaemia. After adjusting by body mass index, waist circumference and triglycerides, the SNP 1304G>A remained significantly associated with hyperglycaemia (OR 2.13; 95%CI 1.18-3.83, p=0.03). Pair wise linkage disequilibrium showed correlation (D′>0.82) between 292C>T and 1304G>A SNPs. Haplotype association with hyperglycaemia also showed significant association between both homozygous mutant alleles (A/T) and hyperglycaemia (OR 1.68; 95%CI 1.01-2.79, p=0.048). Conclusions: Our results suggest that mutant allele A for SNP 1304G>A of SLC38A4 gene is associated with hyperglycaemia. © 2012 John Wiley & Sons, Ltd..
Original languageAmerican English
Pages (from-to)39-43
Number of pages34
JournalDiabetes/Metabolism Research and Reviews
DOIs
StatePublished - 1 Jan 2013

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Hyperglycemia
Single Nucleotide Polymorphism
Genes
Odds Ratio
Gene Frequency
Alleles
Control Groups
Gluconeogenesis
Linkage Disequilibrium
Waist Circumference
Haplotypes
Case-Control Studies
Real-Time Polymerase Chain Reaction
Triglycerides
Body Mass Index
Logistic Models
Regression Analysis
Glucose

Cite this

@article{952f1697e96b4cb78cbfa257702a869b,
title = "Association of the polymorphisms 292C>T and 1304G>A in the SLC38A4 gene with hyperglycaemia",
abstract = "The SLC38A4 gene is related to system 'A' activity, which seems to be related to impaired gluconeogenesis. The objective of this study was to determine whether the 292C>T and 1304G>A polymorphisms of SLC38A4 gene are associated with hyperglycaemia in humans. Methods: A total of 227 individuals were enrolled in a case-control study, in which hyperglycaemia was defined by plasma glucose levels ≥95mg/dL. Genotyping was carried out by using real-time polymerase chain reaction. Results: The frequency of mutant alleles of SLC38A4 gene for single-nucleotide polymorphism (SNP) 1304G>A was 23.6{\%} and 30.2{\%} for SNP 292C>T. The frequency of allele T for the SNP 292C>T in the case and control groups did not show significant differences, whereas the frequency of allele A for the SNP 1304G>A was significantly higher in the case group than in the control group (p=0.04). In the logistic regression analysis, the SNP 1304G>A [odds ratio (OR) 1.78; 95{\%}CI 1.04-3.05, p=0.03] but not SNP 292C>T (OR 1.41; 95{\%}CI 0.80-2.47, p=0.23) showed a significant association with hyperglycaemia. After adjusting by body mass index, waist circumference and triglycerides, the SNP 1304G>A remained significantly associated with hyperglycaemia (OR 2.13; 95{\%}CI 1.18-3.83, p=0.03). Pair wise linkage disequilibrium showed correlation (D′>0.82) between 292C>T and 1304G>A SNPs. Haplotype association with hyperglycaemia also showed significant association between both homozygous mutant alleles (A/T) and hyperglycaemia (OR 1.68; 95{\%}CI 1.01-2.79, p=0.048). Conclusions: Our results suggest that mutant allele A for SNP 1304G>A of SLC38A4 gene is associated with hyperglycaemia. {\circledC} 2012 John Wiley & Sons, Ltd..",
author = "Gonz{\'a}lez-Renteria, {Siblie Marbey} and Ver{\'o}nica Loera-Casta{\~n}eda and Isa{\'i}as Chairez-Hern{\'a}ndez and Martha Sosa-Macias and Norma Paniagua-Castro and Ismael Lares-Aseff and Martha Rodr{\'i}guez-Moran and Fernando Guerrero-Romero and Carlos Galaviz-Hern{\'a}ndez",
year = "2013",
month = "1",
day = "1",
doi = "10.1002/dmrr.2344",
language = "American English",
pages = "39--43",
journal = "Diabetes/Metabolism Research and Reviews",
issn = "1520-7552",
publisher = "John Wiley and Sons Ltd",

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Association of the polymorphisms 292C>T and 1304G>A in the SLC38A4 gene with hyperglycaemia. / González-Renteria, Siblie Marbey; Loera-Castañeda, Verónica; Chairez-Hernández, Isaías; Sosa-Macias, Martha; Paniagua-Castro, Norma; Lares-Aseff, Ismael; Rodríguez-Moran, Martha; Guerrero-Romero, Fernando; Galaviz-Hernández, Carlos.

In: Diabetes/Metabolism Research and Reviews, 01.01.2013, p. 39-43.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Association of the polymorphisms 292C>T and 1304G>A in the SLC38A4 gene with hyperglycaemia

AU - González-Renteria, Siblie Marbey

AU - Loera-Castañeda, Verónica

AU - Chairez-Hernández, Isaías

AU - Sosa-Macias, Martha

AU - Paniagua-Castro, Norma

AU - Lares-Aseff, Ismael

AU - Rodríguez-Moran, Martha

AU - Guerrero-Romero, Fernando

AU - Galaviz-Hernández, Carlos

PY - 2013/1/1

Y1 - 2013/1/1

N2 - The SLC38A4 gene is related to system 'A' activity, which seems to be related to impaired gluconeogenesis. The objective of this study was to determine whether the 292C>T and 1304G>A polymorphisms of SLC38A4 gene are associated with hyperglycaemia in humans. Methods: A total of 227 individuals were enrolled in a case-control study, in which hyperglycaemia was defined by plasma glucose levels ≥95mg/dL. Genotyping was carried out by using real-time polymerase chain reaction. Results: The frequency of mutant alleles of SLC38A4 gene for single-nucleotide polymorphism (SNP) 1304G>A was 23.6% and 30.2% for SNP 292C>T. The frequency of allele T for the SNP 292C>T in the case and control groups did not show significant differences, whereas the frequency of allele A for the SNP 1304G>A was significantly higher in the case group than in the control group (p=0.04). In the logistic regression analysis, the SNP 1304G>A [odds ratio (OR) 1.78; 95%CI 1.04-3.05, p=0.03] but not SNP 292C>T (OR 1.41; 95%CI 0.80-2.47, p=0.23) showed a significant association with hyperglycaemia. After adjusting by body mass index, waist circumference and triglycerides, the SNP 1304G>A remained significantly associated with hyperglycaemia (OR 2.13; 95%CI 1.18-3.83, p=0.03). Pair wise linkage disequilibrium showed correlation (D′>0.82) between 292C>T and 1304G>A SNPs. Haplotype association with hyperglycaemia also showed significant association between both homozygous mutant alleles (A/T) and hyperglycaemia (OR 1.68; 95%CI 1.01-2.79, p=0.048). Conclusions: Our results suggest that mutant allele A for SNP 1304G>A of SLC38A4 gene is associated with hyperglycaemia. © 2012 John Wiley & Sons, Ltd..

AB - The SLC38A4 gene is related to system 'A' activity, which seems to be related to impaired gluconeogenesis. The objective of this study was to determine whether the 292C>T and 1304G>A polymorphisms of SLC38A4 gene are associated with hyperglycaemia in humans. Methods: A total of 227 individuals were enrolled in a case-control study, in which hyperglycaemia was defined by plasma glucose levels ≥95mg/dL. Genotyping was carried out by using real-time polymerase chain reaction. Results: The frequency of mutant alleles of SLC38A4 gene for single-nucleotide polymorphism (SNP) 1304G>A was 23.6% and 30.2% for SNP 292C>T. The frequency of allele T for the SNP 292C>T in the case and control groups did not show significant differences, whereas the frequency of allele A for the SNP 1304G>A was significantly higher in the case group than in the control group (p=0.04). In the logistic regression analysis, the SNP 1304G>A [odds ratio (OR) 1.78; 95%CI 1.04-3.05, p=0.03] but not SNP 292C>T (OR 1.41; 95%CI 0.80-2.47, p=0.23) showed a significant association with hyperglycaemia. After adjusting by body mass index, waist circumference and triglycerides, the SNP 1304G>A remained significantly associated with hyperglycaemia (OR 2.13; 95%CI 1.18-3.83, p=0.03). Pair wise linkage disequilibrium showed correlation (D′>0.82) between 292C>T and 1304G>A SNPs. Haplotype association with hyperglycaemia also showed significant association between both homozygous mutant alleles (A/T) and hyperglycaemia (OR 1.68; 95%CI 1.01-2.79, p=0.048). Conclusions: Our results suggest that mutant allele A for SNP 1304G>A of SLC38A4 gene is associated with hyperglycaemia. © 2012 John Wiley & Sons, Ltd..

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SN - 1520-7552

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