TY - JOUR
T1 - Association of Single-Nucleotide Polymorphisms in Immune-Related Genes with Development of Dengue Hemorrhagic Fever in a Mexican Population
AU - Vargas-Castillo, Angélica Berenice
AU - Ruiz-Tovar, Karina
AU - Vivanco-Cid, Héctor
AU - Quiroz-Cruz, Sarai
AU - Escobar-Gutiérrez, Alejandro
AU - Cerna-Cortes, Jorge Francisco
AU - Vaughan, Gilberto
AU - Fonseca-Coronado, Salvador
N1 - Publisher Copyright:
© 2018 Mary Ann Liebert, Inc.
PY - 2018/4
Y1 - 2018/4
N2 - Single-nucleotide polymorphisms (SNPs) occurring in immune-related genes have been associated with risk or protection for development of dengue, depending on ethnicity. Here, we genotyped seven SNPs located in immune response-related genes to identify their association with severe forms of dengue in patients from an endemic region in Mexico. One hundred and thirty-eight patients with dengue fever (DF), thirty-one dengue hemorrhagic fever (DHF) patients, as well as 304 healthy donors were genotyped by using a TaqMan-based approach. SNP analysis, including rs1800629 (TNF), rs4804803 (CD209), rs2780831 (JAK1), rs1801274 (FCGR2A), rs231775 (CTLA4), rs12979860, and rs8099917 (IFNL3), was performed. The rs1800629 A-allele in the TNF gene was associated with an increased risk of DHF (OR = 3.4, CI = 1.235-9.284 p = 0.0212) whereas SNPs rs4804803, rs2780831, rs1801274, rs231775, rs12979860, and rs8099917 showed no association in this cohort. These results show that allelic variations in TNF can play an important role in the development of DHF. However, the lack of association between all remaining SNPs and DHF suggests that the genetic background might directly modify the role of these immune-related molecules, leading to the milder illness often observed in a Mexican population.
AB - Single-nucleotide polymorphisms (SNPs) occurring in immune-related genes have been associated with risk or protection for development of dengue, depending on ethnicity. Here, we genotyped seven SNPs located in immune response-related genes to identify their association with severe forms of dengue in patients from an endemic region in Mexico. One hundred and thirty-eight patients with dengue fever (DF), thirty-one dengue hemorrhagic fever (DHF) patients, as well as 304 healthy donors were genotyped by using a TaqMan-based approach. SNP analysis, including rs1800629 (TNF), rs4804803 (CD209), rs2780831 (JAK1), rs1801274 (FCGR2A), rs231775 (CTLA4), rs12979860, and rs8099917 (IFNL3), was performed. The rs1800629 A-allele in the TNF gene was associated with an increased risk of DHF (OR = 3.4, CI = 1.235-9.284 p = 0.0212) whereas SNPs rs4804803, rs2780831, rs1801274, rs231775, rs12979860, and rs8099917 showed no association in this cohort. These results show that allelic variations in TNF can play an important role in the development of DHF. However, the lack of association between all remaining SNPs and DHF suggests that the genetic background might directly modify the role of these immune-related molecules, leading to the milder illness often observed in a Mexican population.
KW - Mexican population
KW - TNF-α
KW - dengue
KW - immune-related genes
KW - single-nucleotide polymorphisms
UR - http://www.scopus.com/inward/record.url?scp=85045514724&partnerID=8YFLogxK
U2 - 10.1089/vim.2017.0069
DO - 10.1089/vim.2017.0069
M3 - Artículo
C2 - 29130827
SN - 0882-8245
VL - 31
SP - 249
EP - 255
JO - Viral Immunology
JF - Viral Immunology
IS - 3
ER -