TY - JOUR
T1 - Asociación entre el sistema IGF y PAPP-A en ateroesclerosis coronaria
AU - Fierro-Macías, Alfonso Eduardo
AU - Floriano-Sánchez, Esaú
AU - Mena-Burciaga, Victoria Michelle
AU - Gutiérrez-Leonard, Hugo
AU - Lara-Padilla, Eleazar
AU - Abarca-Rojano, Edgar
AU - Fierro-Almanzán, Alfonso Edmundo
N1 - Publisher Copyright:
© 2016 Instituto Nacional de Cardiología Ignacio Chávez. Published by Masson Doyma México S.A.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Atherosclerosis is a condition that involves multiple pathophysiological mechanisms and whose knowledge has not been fully elucidated. Often, scientific advances on the atherogenic pathophysiology generate that molecules not previously considered in the scene of this disease, were attributed actions on the onset or progression of it. A representative example is the study of a new mechanism involved in the atherogenic process, consisting of the association between the insulin-like growth factor (IGF) system and pregnancy-associated plasma protein-A (PAPP-A). Insulin-like growth factor system is a family of peptides that include 3 peptide hormones, 4 transmembrane receptors and 6 binding proteins. Insulin-like growth factor-1 (IGF-1) is the main ligand of the IGF system involved in coronary atherosclerosis. IGF-1 exerts its effects via activation of the IGF-1R receptor on vascular smooth muscle cells or macrophages. In vascular smooth muscle cells promotes migration and prevents apoptosis which increases plaque stability while in macrophages reduces reverse cholesterol transport leading to the formation of foam cells. Regulation of IGF-1 endothelial bioavailability is carried out by IGFBP proteases, mainly by PAPP-A. In this review, we address the mechanisms between IGF system and PAPPA in atherosclerosis with emphasis on molecular effects on vascular smooth muscle cells and macrophages.
AB - Atherosclerosis is a condition that involves multiple pathophysiological mechanisms and whose knowledge has not been fully elucidated. Often, scientific advances on the atherogenic pathophysiology generate that molecules not previously considered in the scene of this disease, were attributed actions on the onset or progression of it. A representative example is the study of a new mechanism involved in the atherogenic process, consisting of the association between the insulin-like growth factor (IGF) system and pregnancy-associated plasma protein-A (PAPP-A). Insulin-like growth factor system is a family of peptides that include 3 peptide hormones, 4 transmembrane receptors and 6 binding proteins. Insulin-like growth factor-1 (IGF-1) is the main ligand of the IGF system involved in coronary atherosclerosis. IGF-1 exerts its effects via activation of the IGF-1R receptor on vascular smooth muscle cells or macrophages. In vascular smooth muscle cells promotes migration and prevents apoptosis which increases plaque stability while in macrophages reduces reverse cholesterol transport leading to the formation of foam cells. Regulation of IGF-1 endothelial bioavailability is carried out by IGFBP proteases, mainly by PAPP-A. In this review, we address the mechanisms between IGF system and PAPPA in atherosclerosis with emphasis on molecular effects on vascular smooth muscle cells and macrophages.
KW - Atherosclerosis
KW - Insulin-like growth factor binding proteins
KW - Insulin-like growth factor system
KW - Insulin-like growth factor-1
KW - Mexico
KW - Pregnancy-associated plasma protein-A
UR - http://www.scopus.com/inward/record.url?scp=84964843370&partnerID=8YFLogxK
U2 - 10.1016/j.acmx.2015.12.006
DO - 10.1016/j.acmx.2015.12.006
M3 - Estudio breve
C2 - 26906607
SN - 1405-9940
VL - 86
SP - 148
EP - 156
JO - Archivos de Cardiologia de Mexico
JF - Archivos de Cardiologia de Mexico
IS - 2
ER -