Assessments of antioxidant content and the anti-carcinogenic effect of extracts of Solanum rostratum dunal in human cancer cells

In Mexico, Solanum rostratum has been employed for the treatment of several diseases, including uterine cancer. The aim of this study was to evaluate antioxidant and anti-carcinogenic activities of S. rostratum Dunal extracts on the breast and uterine cancer cell lines, MDA and SiHa, respectively. The methanolic, ethyl acetate, and hexane extracts of the aerial parts of S. rostratum were tested for phenol concentration, antioxidant activity, and anti-carcinogenic effects. The leaves extracts showed the highest content of phenols; however, the flower-fruits extracts showed higher scavenging activity. On the other hand, ethyl acetate extracts exhibited the highest anti-carcinogenic effects on these cells, while methanolic extracts showed the least effects. The results of this work indicate that S. rostratum is a promising source of antioxidants, and the extracts exert dose-dependent anti-carcinogenic effects on both cell lines.