Evaluación de un modelo de diabetes tipo 2 para estudiar la actividad hipoglicemieante de la glibenclamida

Translated title of the contribution: Assessment of diabetes type 2 model to study the hypoglycemic activity of glibenclamide

Araceli Amaya-Chávez, Emilia Dolores-Ledezma, Patricia Álvarez-Sánchez, Guillermo Ferreira-Rubio, Leobardo Manuel Gómez-Oliván, Marcela Galar-Martínez

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A type 2 diabetes model, consisting in the sequential administration of nicotinamide-streptozotocin (225 y 65 mg/kg respectively) to male Wistar rats, was evaluated and subsequently treated with glibenclamide, by acute and subacute tests. Parallel designs were used; the first one to establish the nicotinamide dose which protects against the total destruction of β cells, produced by the streptozotocin and the second one to determine the glibenclamide dose that produces the hypoglycemic effect in the model. The evaluation was done by blood glucose measures and pancreas histological studies. The results showed that this model is adequate for the acute study, but it is necessary to test other nicotinamide doses which may efficiently protect pancreatic β cells from the total destruction produced by the streptozotocin, and that may be useful for subacute or chronic studies, in order to employ it for the efficiency evaluation of other hypoglycemiant drugs.

Translated title of the contributionAssessment of diabetes type 2 model to study the hypoglycemic activity of glibenclamide
Original languageSpanish
Pages (from-to)5-11
Number of pages7
JournalRevista Mexicana de Ciencias Farmaceuticas
Volume38
Issue number3
StatePublished - Jul 2007

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