TY - JOUR
T1 - Asociación entre el “food craving” y los genes del gusto en personas con obesidad
AU - Marín-Soto, María Delfina
AU - Miliar-García, Angel
AU - Gómez-López, Modesto
AU - González-Mundo, Ilicia
AU - Aguilera-Sosa, Víctor Ricardo
N1 - Publisher Copyright:
© 2021, Instituto de Investigaciones Clinicas. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Food craving (FC) is an uncontrollable desire to eat specific foods, and it is activated during the withdrawal phase of eating foods, com-monly sugary, salty or fatty. Comorbidity has been found with obesity (OB) and eating behavior disorders, as well as being a negative factor for adherence to OB treatments. Trait and State Food-Cravings Questionnaires, are validated instru-ments, that measure trait and state; both are reliable, with high internal consis-tency (ɑ> 0.90). The objective, was to analyze differences in normal weight and obese subjects, in scores of the FCQ Trait and State, and their correlation with gene expression DRD2, TAS1R2, TAS1R3 and TAS2R43. It was a correlational, cross-sectional study of cases and controls, non-probabilistic sampling, and at convenience; n= 40 adults, both sexes between 18-45 years, 20 normal weight and 20 obese, from Mexico City and the State of Mexico. BMI, gene expression and FC were evaluated. Significant differences were found (p <0.05) in rela-tive expression of TAS1R2, and positive correlation between FCQ and TAS1R2 expression in obese; in turn we found that FCQ-T and FCQ-S predict gene expression of TAS1R2 and TAS2R43 in men, and in women of TAS1R2, TAS2R43 and DRD2. This research offers new perspectives to understand the association between FC with the sweet taste receptor (TAS1R2), evidencing the link with molecular components, which together influence the explanation of the development of addiction to sugary foods in OB.
AB - Food craving (FC) is an uncontrollable desire to eat specific foods, and it is activated during the withdrawal phase of eating foods, com-monly sugary, salty or fatty. Comorbidity has been found with obesity (OB) and eating behavior disorders, as well as being a negative factor for adherence to OB treatments. Trait and State Food-Cravings Questionnaires, are validated instru-ments, that measure trait and state; both are reliable, with high internal consis-tency (ɑ> 0.90). The objective, was to analyze differences in normal weight and obese subjects, in scores of the FCQ Trait and State, and their correlation with gene expression DRD2, TAS1R2, TAS1R3 and TAS2R43. It was a correlational, cross-sectional study of cases and controls, non-probabilistic sampling, and at convenience; n= 40 adults, both sexes between 18-45 years, 20 normal weight and 20 obese, from Mexico City and the State of Mexico. BMI, gene expression and FC were evaluated. Significant differences were found (p <0.05) in rela-tive expression of TAS1R2, and positive correlation between FCQ and TAS1R2 expression in obese; in turn we found that FCQ-T and FCQ-S predict gene expression of TAS1R2 and TAS2R43 in men, and in women of TAS1R2, TAS2R43 and DRD2. This research offers new perspectives to understand the association between FC with the sweet taste receptor (TAS1R2), evidencing the link with molecular components, which together influence the explanation of the development of addiction to sugary foods in OB.
KW - FCQ-Trate & FCQ-State
KW - Food craving
KW - Gene expression
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=85109818134&partnerID=8YFLogxK
U2 - 10.22209/IC.V62N2A03
DO - 10.22209/IC.V62N2A03
M3 - Artículo
AN - SCOPUS:85109818134
SN - 0535-5133
VL - 62
SP - 119
EP - 131
JO - Investigacion Clinica
JF - Investigacion Clinica
IS - 2
ER -