Arsenic exposure: A public health problem leading to several cancers

I. Palma-Lara, M. Martínez-Castillo, J. C. Quintana-Pérez, M. G. Arellano-Mendoza, F. Tamay-Cach, O. L. Valenzuela-Limón, E. A. García-Montalvo, A. Hernández-Zavala

Research output: Contribution to journalReview article

Abstract

Arsenic, a metalloid and naturally occurring element, is one of the most abundant elements in the earth's crust. Water is contaminated by arsenic through natural sources (underground water, minerals and geothermal processes) and anthropogenic sources such as mining, industrial processes, and the production and use of pesticides. Humans are exposed to arsenic mainly by drinking contaminated water, and secondarily through inhalation and skin contact. Arsenic exposure is associated with the development of vascular disease, including stroke, ischemic heart disease and peripheral vascular disease. Also, arsenic increases the risk of tumors of bladder, lungs, kidneys and liver, according to the International Agency for Research on Cancer and the Food and Drug Administration. Once ingested, an estimated 70–90% of inorganic arsenic is absorbed by the gastrointestinal tract and widely distributed through the blood to different organs, primarily to the liver, kidneys, lungs and bladder and secondarily to muscle and nerve tissue. Arsenic accumulates in the organs, especially in the liver. Its excretion mostly takes place through urination. The toxicokinetics of arsenic depends on the duration of exposure, pathway of ingestion, physicochemical characteristics of the compound, and affected biological species. The present review outlines of arsenic toxic effects focusing on different cancer types whit highest prevalence's by exposure to this metalloid and signaling pathways of carcinogenesis.

Original languageEnglish
Article number104539
JournalRegulatory Toxicology and Pharmacology
Volume110
DOIs
StatePublished - Feb 2020

Fingerprint

Arsenic
Public health
Medical problems
Public Health
Neoplasms
Metalloids
Liver
International Agencies
Kidney
Mineral Waters
Nerve Tissue
Lung
Peripheral Vascular Diseases
Urination
Poisons
Groundwater
United States Food and Drug Administration
Vascular Diseases
Pesticides
Urinary Bladder Neoplasms

Keywords

  • Arsenic
  • Bladder
  • Molecular mechanism
  • Skin and lung cancer

Cite this

Palma-Lara, I. ; Martínez-Castillo, M. ; Quintana-Pérez, J. C. ; Arellano-Mendoza, M. G. ; Tamay-Cach, F. ; Valenzuela-Limón, O. L. ; García-Montalvo, E. A. ; Hernández-Zavala, A. / Arsenic exposure : A public health problem leading to several cancers. In: Regulatory Toxicology and Pharmacology. 2020 ; Vol. 110.
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Arsenic exposure : A public health problem leading to several cancers. / Palma-Lara, I.; Martínez-Castillo, M.; Quintana-Pérez, J. C.; Arellano-Mendoza, M. G.; Tamay-Cach, F.; Valenzuela-Limón, O. L.; García-Montalvo, E. A.; Hernández-Zavala, A.

In: Regulatory Toxicology and Pharmacology, Vol. 110, 104539, 02.2020.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Arsenic exposure

T2 - A public health problem leading to several cancers

AU - Palma-Lara, I.

AU - Martínez-Castillo, M.

AU - Quintana-Pérez, J. C.

AU - Arellano-Mendoza, M. G.

AU - Tamay-Cach, F.

AU - Valenzuela-Limón, O. L.

AU - García-Montalvo, E. A.

AU - Hernández-Zavala, A.

PY - 2020/2

Y1 - 2020/2

N2 - Arsenic, a metalloid and naturally occurring element, is one of the most abundant elements in the earth's crust. Water is contaminated by arsenic through natural sources (underground water, minerals and geothermal processes) and anthropogenic sources such as mining, industrial processes, and the production and use of pesticides. Humans are exposed to arsenic mainly by drinking contaminated water, and secondarily through inhalation and skin contact. Arsenic exposure is associated with the development of vascular disease, including stroke, ischemic heart disease and peripheral vascular disease. Also, arsenic increases the risk of tumors of bladder, lungs, kidneys and liver, according to the International Agency for Research on Cancer and the Food and Drug Administration. Once ingested, an estimated 70–90% of inorganic arsenic is absorbed by the gastrointestinal tract and widely distributed through the blood to different organs, primarily to the liver, kidneys, lungs and bladder and secondarily to muscle and nerve tissue. Arsenic accumulates in the organs, especially in the liver. Its excretion mostly takes place through urination. The toxicokinetics of arsenic depends on the duration of exposure, pathway of ingestion, physicochemical characteristics of the compound, and affected biological species. The present review outlines of arsenic toxic effects focusing on different cancer types whit highest prevalence's by exposure to this metalloid and signaling pathways of carcinogenesis.

AB - Arsenic, a metalloid and naturally occurring element, is one of the most abundant elements in the earth's crust. Water is contaminated by arsenic through natural sources (underground water, minerals and geothermal processes) and anthropogenic sources such as mining, industrial processes, and the production and use of pesticides. Humans are exposed to arsenic mainly by drinking contaminated water, and secondarily through inhalation and skin contact. Arsenic exposure is associated with the development of vascular disease, including stroke, ischemic heart disease and peripheral vascular disease. Also, arsenic increases the risk of tumors of bladder, lungs, kidneys and liver, according to the International Agency for Research on Cancer and the Food and Drug Administration. Once ingested, an estimated 70–90% of inorganic arsenic is absorbed by the gastrointestinal tract and widely distributed through the blood to different organs, primarily to the liver, kidneys, lungs and bladder and secondarily to muscle and nerve tissue. Arsenic accumulates in the organs, especially in the liver. Its excretion mostly takes place through urination. The toxicokinetics of arsenic depends on the duration of exposure, pathway of ingestion, physicochemical characteristics of the compound, and affected biological species. The present review outlines of arsenic toxic effects focusing on different cancer types whit highest prevalence's by exposure to this metalloid and signaling pathways of carcinogenesis.

KW - Arsenic

KW - Bladder

KW - Molecular mechanism

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