Apocynin combined with drugs as coadjuvant could be employed to prevent and/or treat the chronic kidney disease

Jorge Osvaldo Montes-Rivera, Feliciano Tamay-Cach, Julio César Quintana-Pérez, Juan Alberto Guevara-Salazar, José Guadalupe Trujillo-Ferrara, Leonardo Del Valle-Mondragón, Mónica Griselda Arellano-Mendoza

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

© 2018 The Author(s). A worldwide public health problem is chronic kidney disease (CKD) presenting alarming epidemiological data. It currently affects about 10% of the adult population worldwide and has a high mortality rate. It is now known that oxidative stress represents one of the most important mechanisms in its pathophysiology, from the early stages to the terminal phase. Oxidation increases inflammation and reduces the capacity of NO• to relax vascular smooth muscle, in part by decreasing bioavailability of tetrahydrobiopterin (BH4), leading to endothelial dysfunction and high blood pressure, and due to the limited effectiveness of existing treatments, new drugs are needed to prevent and/or treat these mechanisms. The aim of this study was to test apocynin in a 5/6 nephrectomy mouse model of CKD to investigate whether its known antioxidant effect can improve the disease outcome. This effect results from the inhibition of NADPH oxidase and consequently a reduced production of the superoxide anion (O2•-). Animals were divided into five groups: sham, 5/6 nephrectomy only, and 5/6 nephrectomy followed by treatment with captopril, losartan or apocynin. The parameters evaluated were blood pressure and markers of oxidative stress (O2•-) and endothelial function (BH4). There were significantly lower levels of and a greater availability of serum BH4 in the apocynin-treated animals versus the control group and the two other drug treatments. The present findings suggest that apocynin in conjunction with a coadjuvant for modulating blood pressure may be useful for controlling the progression of CRF.
Original languageAmerican English
Pages (from-to)92-98
Number of pages82
JournalRenal Failure
DOIs
StatePublished - 15 Oct 2018

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Chronic Renal Insufficiency
Nephrectomy
Pharmaceutical Preparations
Oxidative Stress
Blood Pressure
Losartan
NADPH Oxidase
Captopril
Vascular Smooth Muscle
Superoxides
Biological Availability
Public Health
Antioxidants
Hypertension
Inflammation
Control Groups
Mortality
acetovanillone
Serum
Population

Cite this

Montes-Rivera, Jorge Osvaldo ; Tamay-Cach, Feliciano ; Quintana-Pérez, Julio César ; Guevara-Salazar, Juan Alberto ; Trujillo-Ferrara, José Guadalupe ; Del Valle-Mondragón, Leonardo ; Arellano-Mendoza, Mónica Griselda. / Apocynin combined with drugs as coadjuvant could be employed to prevent and/or treat the chronic kidney disease. In: Renal Failure. 2018 ; pp. 92-98.
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abstract = "{\circledC} 2018 The Author(s). A worldwide public health problem is chronic kidney disease (CKD) presenting alarming epidemiological data. It currently affects about 10{\%} of the adult population worldwide and has a high mortality rate. It is now known that oxidative stress represents one of the most important mechanisms in its pathophysiology, from the early stages to the terminal phase. Oxidation increases inflammation and reduces the capacity of NO• to relax vascular smooth muscle, in part by decreasing bioavailability of tetrahydrobiopterin (BH4), leading to endothelial dysfunction and high blood pressure, and due to the limited effectiveness of existing treatments, new drugs are needed to prevent and/or treat these mechanisms. The aim of this study was to test apocynin in a 5/6 nephrectomy mouse model of CKD to investigate whether its known antioxidant effect can improve the disease outcome. This effect results from the inhibition of NADPH oxidase and consequently a reduced production of the superoxide anion (O2•-). Animals were divided into five groups: sham, 5/6 nephrectomy only, and 5/6 nephrectomy followed by treatment with captopril, losartan or apocynin. The parameters evaluated were blood pressure and markers of oxidative stress (O2•-) and endothelial function (BH4). There were significantly lower levels of and a greater availability of serum BH4 in the apocynin-treated animals versus the control group and the two other drug treatments. The present findings suggest that apocynin in conjunction with a coadjuvant for modulating blood pressure may be useful for controlling the progression of CRF.",
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Apocynin combined with drugs as coadjuvant could be employed to prevent and/or treat the chronic kidney disease. / Montes-Rivera, Jorge Osvaldo; Tamay-Cach, Feliciano; Quintana-Pérez, Julio César; Guevara-Salazar, Juan Alberto; Trujillo-Ferrara, José Guadalupe; Del Valle-Mondragón, Leonardo; Arellano-Mendoza, Mónica Griselda.

In: Renal Failure, 15.10.2018, p. 92-98.

Research output: Contribution to journalArticle

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AU - Montes-Rivera, Jorge Osvaldo

AU - Tamay-Cach, Feliciano

AU - Quintana-Pérez, Julio César

AU - Guevara-Salazar, Juan Alberto

AU - Trujillo-Ferrara, José Guadalupe

AU - Del Valle-Mondragón, Leonardo

AU - Arellano-Mendoza, Mónica Griselda

PY - 2018/10/15

Y1 - 2018/10/15

N2 - © 2018 The Author(s). A worldwide public health problem is chronic kidney disease (CKD) presenting alarming epidemiological data. It currently affects about 10% of the adult population worldwide and has a high mortality rate. It is now known that oxidative stress represents one of the most important mechanisms in its pathophysiology, from the early stages to the terminal phase. Oxidation increases inflammation and reduces the capacity of NO• to relax vascular smooth muscle, in part by decreasing bioavailability of tetrahydrobiopterin (BH4), leading to endothelial dysfunction and high blood pressure, and due to the limited effectiveness of existing treatments, new drugs are needed to prevent and/or treat these mechanisms. The aim of this study was to test apocynin in a 5/6 nephrectomy mouse model of CKD to investigate whether its known antioxidant effect can improve the disease outcome. This effect results from the inhibition of NADPH oxidase and consequently a reduced production of the superoxide anion (O2•-). Animals were divided into five groups: sham, 5/6 nephrectomy only, and 5/6 nephrectomy followed by treatment with captopril, losartan or apocynin. The parameters evaluated were blood pressure and markers of oxidative stress (O2•-) and endothelial function (BH4). There were significantly lower levels of and a greater availability of serum BH4 in the apocynin-treated animals versus the control group and the two other drug treatments. The present findings suggest that apocynin in conjunction with a coadjuvant for modulating blood pressure may be useful for controlling the progression of CRF.

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