Antituberculosis activity of clarithromycin

J. Luna-Herrera, V. M. Reddy, D. Daneluzzi, P. R.J. Gangadharam

Research output: Contribution to journalArticleResearchpeer-review

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Abstract

Antituberculosis activity of clarithromycin (CLA), a macrolide antibiotic, was investigated in vitro, in macrophages, and in C57BL/6 mice. CLA showed high in vitro MICs (4 to > 16 μg/ml) for several strains of Mycobacterium tuberculosis and caused slight enhancement of activity of rifampin (RIF) against H37Rv but failed to increase the activity of either RIF or isoniazid (INH) against other strains. However, inside J774A.1 macrophages, CLA showed high activity and was synergistic with RIF against some strains of tubercle bacilli susceptible or resistant to INH and RIF. In the in vivo studies with a drug-susceptible strain (H37Rv), CLA protected mice from mortality due to tuberculosis for up to 8 weeks of observation. The CFU data for lungs and spleens revealed that the antituberculosis activity of CLA is inferior to those of INH and streptomycin. However, the activity of CLA when used alone or in combination was comparable to that of thiacetazone, indicating its potential usefulness as a secondary drug for the treatment of tuberculosis.
Original languageAmerican English
Pages (from-to)2692-2695
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
DOIs
StatePublished - 1 Jan 1995
Externally publishedYes

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Clarithromycin
Rifampin
Tuberculosis
Thioacetazone
Macrophages
Macrolides
Isoniazid
Streptomycin
Inbred C57BL Mouse
Mycobacterium tuberculosis
Pharmaceutical Preparations
Bacillus
Spleen
Observation
Anti-Bacterial Agents
Lung
Mortality

Cite this

Luna-Herrera, J. ; Reddy, V. M. ; Daneluzzi, D. ; Gangadharam, P. R.J. / Antituberculosis activity of clarithromycin. In: Antimicrobial Agents and Chemotherapy. 1995 ; pp. 2692-2695.
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Antituberculosis activity of clarithromycin. / Luna-Herrera, J.; Reddy, V. M.; Daneluzzi, D.; Gangadharam, P. R.J.

In: Antimicrobial Agents and Chemotherapy, 01.01.1995, p. 2692-2695.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Antituberculosis activity of clarithromycin

AU - Luna-Herrera, J.

AU - Reddy, V. M.

AU - Daneluzzi, D.

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PY - 1995/1/1

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N2 - Antituberculosis activity of clarithromycin (CLA), a macrolide antibiotic, was investigated in vitro, in macrophages, and in C57BL/6 mice. CLA showed high in vitro MICs (4 to > 16 μg/ml) for several strains of Mycobacterium tuberculosis and caused slight enhancement of activity of rifampin (RIF) against H37Rv but failed to increase the activity of either RIF or isoniazid (INH) against other strains. However, inside J774A.1 macrophages, CLA showed high activity and was synergistic with RIF against some strains of tubercle bacilli susceptible or resistant to INH and RIF. In the in vivo studies with a drug-susceptible strain (H37Rv), CLA protected mice from mortality due to tuberculosis for up to 8 weeks of observation. The CFU data for lungs and spleens revealed that the antituberculosis activity of CLA is inferior to those of INH and streptomycin. However, the activity of CLA when used alone or in combination was comparable to that of thiacetazone, indicating its potential usefulness as a secondary drug for the treatment of tuberculosis.

AB - Antituberculosis activity of clarithromycin (CLA), a macrolide antibiotic, was investigated in vitro, in macrophages, and in C57BL/6 mice. CLA showed high in vitro MICs (4 to > 16 μg/ml) for several strains of Mycobacterium tuberculosis and caused slight enhancement of activity of rifampin (RIF) against H37Rv but failed to increase the activity of either RIF or isoniazid (INH) against other strains. However, inside J774A.1 macrophages, CLA showed high activity and was synergistic with RIF against some strains of tubercle bacilli susceptible or resistant to INH and RIF. In the in vivo studies with a drug-susceptible strain (H37Rv), CLA protected mice from mortality due to tuberculosis for up to 8 weeks of observation. The CFU data for lungs and spleens revealed that the antituberculosis activity of CLA is inferior to those of INH and streptomycin. However, the activity of CLA when used alone or in combination was comparable to that of thiacetazone, indicating its potential usefulness as a secondary drug for the treatment of tuberculosis.

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