Antispasmodic and relaxant activity from the freshwater cyanobacteria Blennothrix ganeshii and Microcoleous lacustris extracts

Rosa Martha Pérez Gutiérrez, Rosario Vargas Solis

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

The discovery of novel compounds with pharmaceutical application in cyanobacterias suggests that Blennothrix ganeshii and Microcoleous lacustris Mexican species can be candidates for the bioprocess of target compounds. The antispasmodic effect of hexane, chloroform, methanol and water extracts of B. ganeshii and M. lacustris were studied in vitro in guinea pig ileum against three spasmogens; acetylcholine, histamine and barium chloride. In all cases, the hexane extract produces a significant antispasmodic effect on the contractions of the rat ileum induced by acetylcholine, histamine and barium chloride. The inhibitory concentration for each was determined. These results show that hexane extract of B. ganeshii, and M. lacustris possesses both anticholinergic and antihistaminic properties. © 2009 Academic Journals.
Original languageAmerican English
Pages (from-to)403-407
Number of pages362
JournalJournal of Medicinal Plants Research
StatePublished - 1 Dec 2009
Externally publishedYes

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parasympatholytics
Parasympatholytics
Cyanobacteria
Hexanes
Fresh Water
hexane
barium
acetylcholine
histamine
Ileum
ileum
Histamine
Acetylcholine
chlorides
extracts
antihistamines
Cholinergic Antagonists
Chloroform
chloroform
guinea pigs

Cite this

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abstract = "The discovery of novel compounds with pharmaceutical application in cyanobacterias suggests that Blennothrix ganeshii and Microcoleous lacustris Mexican species can be candidates for the bioprocess of target compounds. The antispasmodic effect of hexane, chloroform, methanol and water extracts of B. ganeshii and M. lacustris were studied in vitro in guinea pig ileum against three spasmogens; acetylcholine, histamine and barium chloride. In all cases, the hexane extract produces a significant antispasmodic effect on the contractions of the rat ileum induced by acetylcholine, histamine and barium chloride. The inhibitory concentration for each was determined. These results show that hexane extract of B. ganeshii, and M. lacustris possesses both anticholinergic and antihistaminic properties. {\circledC} 2009 Academic Journals.",
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Antispasmodic and relaxant activity from the freshwater cyanobacteria Blennothrix ganeshii and Microcoleous lacustris extracts. / Gutiérrez, Rosa Martha Pérez; Solis, Rosario Vargas.

In: Journal of Medicinal Plants Research, 01.12.2009, p. 403-407.

Research output: Contribution to journalArticleResearchpeer-review

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