Antioxidative diet supplementation reverses high-fat diet-induced increases of cardiovascular risk factors in mice

Hilda Vargas-Robles, Amelia Rios, Monica Arellano-Mendoza, Bruno A. Escalante, Michael Schnoor

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

© 2015 Hilda Vargas-Robles et al. Obesity is a worldwide epidemic that is characterized not only by excessive fat deposition but also by systemic microinflammation, high oxidative stress, and increased cardiovascular risk factors. While diets enriched in natural antioxidants showed beneficial effects on oxidative stress, blood pressure, and serum lipid composition, diet supplementation with synthetic antioxidants showed contradictive results. Thus, we tested in C57Bl/6 mice whether a daily dosage of an antioxidative mixture consisting of vitamin C, vitamin E, L-arginine, eicosapentaenoic acid, and docosahexaenoic acid (corabion) would affect cardiovascular risk factors associated with obesity. Obese mice showed increased serum triglyceride and glucose levels and hypertension after eight weeks of being fed a high-fat diet (HFD). Importantly, corabion ameliorated all of these symptoms significantly. Oxidative stress and early signs of systemic microinflammation already developed after two weeks of high-fat diet and were significantly reduced by daily doses of corabion. Of note, the beneficial effects of corabion could not be observed when applying its single antioxidative components suggesting that a combination of various nutrients is required to counteract HFD-induced cardiovascular risk factors. Thus, daily consumption of corabion may be beneficial for the management of obesity-related cardiovascular complications.
Original languageAmerican English
JournalOxidative Medicine and Cellular Longevity
DOIs
StatePublished - 1 Jan 2015

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High Fat Diet
Nutrition
Oxidative Stress
Obesity
Fats
Oxidative stress
Diet
Antioxidants
Obese Mice
Eicosapentaenoic Acid
Docosahexaenoic Acids
Serum
Vitamin E
Ascorbic Acid
Arginine
Triglycerides
Blood Pressure
Hypertension
Blood pressure
Lipids

Cite this

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title = "Antioxidative diet supplementation reverses high-fat diet-induced increases of cardiovascular risk factors in mice",
abstract = "{\circledC} 2015 Hilda Vargas-Robles et al. Obesity is a worldwide epidemic that is characterized not only by excessive fat deposition but also by systemic microinflammation, high oxidative stress, and increased cardiovascular risk factors. While diets enriched in natural antioxidants showed beneficial effects on oxidative stress, blood pressure, and serum lipid composition, diet supplementation with synthetic antioxidants showed contradictive results. Thus, we tested in C57Bl/6 mice whether a daily dosage of an antioxidative mixture consisting of vitamin C, vitamin E, L-arginine, eicosapentaenoic acid, and docosahexaenoic acid (corabion) would affect cardiovascular risk factors associated with obesity. Obese mice showed increased serum triglyceride and glucose levels and hypertension after eight weeks of being fed a high-fat diet (HFD). Importantly, corabion ameliorated all of these symptoms significantly. Oxidative stress and early signs of systemic microinflammation already developed after two weeks of high-fat diet and were significantly reduced by daily doses of corabion. Of note, the beneficial effects of corabion could not be observed when applying its single antioxidative components suggesting that a combination of various nutrients is required to counteract HFD-induced cardiovascular risk factors. Thus, daily consumption of corabion may be beneficial for the management of obesity-related cardiovascular complications.",
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Antioxidative diet supplementation reverses high-fat diet-induced increases of cardiovascular risk factors in mice. / Vargas-Robles, Hilda; Rios, Amelia; Arellano-Mendoza, Monica; Escalante, Bruno A.; Schnoor, Michael.

In: Oxidative Medicine and Cellular Longevity, 01.01.2015.

Research output: Contribution to journalArticle

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