Antioxidant supplementation has a positive effect on oxidative stress and hematological toxicity during oncology treatment in cervical cancer patients

Vanessa Fuchs-Tarlovsky, María Amanda Casillas Rivera, Karolina Alvarez Altamirano, Juan Carlos Lopez-Alvarenga, Guillermo Manuel Ceballos-Reyes

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

Background and aim: Hematological toxicity and oxidative stress are common in cancer patients. Antioxidant supplementation has been shown to decrease oxidative stress, but there is still controversy on this topic. The aim of this study was to determine the effect of antioxidant supplementation on oxidative stress, hematological toxicity, and quality of life (QoL) in cervical cancer patients. Methods: Randomized, single-blinded controlled trial in women with cervical cancer treated with radiotherapy and chemotherapy with cisplatin. Subjects were randomly assigned to receive antioxidant supplement or placebo supplement. Plasma concentrations of malondialdehyde, free carbonyls, and blood biometry were measured. EORTC quality of life questionnaire was applied before and after oncology treatment. Student's t test for independent samples and X2for categorical variables were performed. Results: One hundred three patients were randomly assigned to receive treatment with antioxidants 49 (48 %) or placebo 54 (52.40 %). At the end of the oncology treatment, hemoglobin levels were maintained, and global QoL was better only in the supplemented group (p < 0.025). Conclusions: Antioxidant supplementation in patients treated with chemotherapy and radiotherapy apparently decreased oxidative stress, maintained hemoglobin levels, and improved QoL; however, more studies are needed to study the long-term effect of this intervention. © 2012 Springer-Verlag Berlin Heidelberg.
Original languageAmerican English
Pages (from-to)1359-1363
Number of pages1222
JournalSupportive Care in Cancer
DOIs
StatePublished - 1 May 2013

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Uterine Cervical Neoplasms
Oxidative Stress
Antioxidants
Quality of Life
Hemoglobins
Radiotherapy
Placebos
Biometry
Therapeutics
Drug Therapy
Berlin
Malondialdehyde
Cisplatin
Students
Neoplasms

Cite this

Fuchs-Tarlovsky, Vanessa ; Rivera, María Amanda Casillas ; Altamirano, Karolina Alvarez ; Lopez-Alvarenga, Juan Carlos ; Ceballos-Reyes, Guillermo Manuel. / Antioxidant supplementation has a positive effect on oxidative stress and hematological toxicity during oncology treatment in cervical cancer patients. In: Supportive Care in Cancer. 2013 ; pp. 1359-1363.
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abstract = "Background and aim: Hematological toxicity and oxidative stress are common in cancer patients. Antioxidant supplementation has been shown to decrease oxidative stress, but there is still controversy on this topic. The aim of this study was to determine the effect of antioxidant supplementation on oxidative stress, hematological toxicity, and quality of life (QoL) in cervical cancer patients. Methods: Randomized, single-blinded controlled trial in women with cervical cancer treated with radiotherapy and chemotherapy with cisplatin. Subjects were randomly assigned to receive antioxidant supplement or placebo supplement. Plasma concentrations of malondialdehyde, free carbonyls, and blood biometry were measured. EORTC quality of life questionnaire was applied before and after oncology treatment. Student's t test for independent samples and X2for categorical variables were performed. Results: One hundred three patients were randomly assigned to receive treatment with antioxidants 49 (48 {\%}) or placebo 54 (52.40 {\%}). At the end of the oncology treatment, hemoglobin levels were maintained, and global QoL was better only in the supplemented group (p < 0.025). Conclusions: Antioxidant supplementation in patients treated with chemotherapy and radiotherapy apparently decreased oxidative stress, maintained hemoglobin levels, and improved QoL; however, more studies are needed to study the long-term effect of this intervention. {\circledC} 2012 Springer-Verlag Berlin Heidelberg.",
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Antioxidant supplementation has a positive effect on oxidative stress and hematological toxicity during oncology treatment in cervical cancer patients. / Fuchs-Tarlovsky, Vanessa; Rivera, María Amanda Casillas; Altamirano, Karolina Alvarez; Lopez-Alvarenga, Juan Carlos; Ceballos-Reyes, Guillermo Manuel.

In: Supportive Care in Cancer, 01.05.2013, p. 1359-1363.

Research output: Contribution to journalArticleResearchpeer-review

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