Antinociceptive Potential of Zinnia grandiflora

Valeria Reyes-Pérez, Araceli Pérez Vásquez, Myrna Déciga-Campos, Robert Bye, Edelmira Linares, Rachel Mata

Research output: Contribution to journalArticleResearchpeer-review

Abstract

© 2018 American Chemical Society and American Society of Pharmacognosy. An aqueous extract prepared from the aerial parts of Zinnia grandiflora was found not to induce acute toxicity (LD 50 > 5g/kg, p.o.) in mice when tested by the Lorke method. This extract showed notable antinociceptive and anti-inflammatory actions when evaluated by the formalin- (ED 50 = 224.62 ± 38.17 mg/kg, p.o.) and the carrageenan-induced paw edema models in mice, respectively. The organic-soluble fractions obtained by partitioning the infusion with CH 2 Cl 2 and EtOAc were also active in the formalin test. The most important antinociceptive effect was observed with the CH 2 Cl 2 fraction; extensive fractionation of the latter yielded three new elemanolides, namely, zinagranolides D-F (1-3), which were characterized structurally by spectroscopic means. The structure of compound 2 was established unequivocally by an X-ray crystallographic analysis. This compound exerted a significant antinociceptive effect in the formalin assay, better than that of diclofenac used as a positive control.
Original languageAmerican English
Pages (from-to)456-461
Number of pages409
JournalJournal of Natural Products
DOIs
StatePublished - 22 Mar 2019

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Formaldehyde
Diclofenac
Carrageenan
Pain Measurement
Edema
Anti-Inflammatory Agents
X-Rays
Fractionation
Toxicity
Assays
Antennas
X rays

Cite this

Reyes-Pérez, Valeria ; Vásquez, Araceli Pérez ; Déciga-Campos, Myrna ; Bye, Robert ; Linares, Edelmira ; Mata, Rachel. / Antinociceptive Potential of Zinnia grandiflora. In: Journal of Natural Products. 2019 ; pp. 456-461.
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abstract = "{\circledC} 2018 American Chemical Society and American Society of Pharmacognosy. An aqueous extract prepared from the aerial parts of Zinnia grandiflora was found not to induce acute toxicity (LD 50 > 5g/kg, p.o.) in mice when tested by the Lorke method. This extract showed notable antinociceptive and anti-inflammatory actions when evaluated by the formalin- (ED 50 = 224.62 ± 38.17 mg/kg, p.o.) and the carrageenan-induced paw edema models in mice, respectively. The organic-soluble fractions obtained by partitioning the infusion with CH 2 Cl 2 and EtOAc were also active in the formalin test. The most important antinociceptive effect was observed with the CH 2 Cl 2 fraction; extensive fractionation of the latter yielded three new elemanolides, namely, zinagranolides D-F (1-3), which were characterized structurally by spectroscopic means. The structure of compound 2 was established unequivocally by an X-ray crystallographic analysis. This compound exerted a significant antinociceptive effect in the formalin assay, better than that of diclofenac used as a positive control.",
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Antinociceptive Potential of Zinnia grandiflora. / Reyes-Pérez, Valeria; Vásquez, Araceli Pérez; Déciga-Campos, Myrna; Bye, Robert; Linares, Edelmira; Mata, Rachel.

In: Journal of Natural Products, 22.03.2019, p. 456-461.

Research output: Contribution to journalArticleResearchpeer-review

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