TY - JOUR
T1 - Antinociceptive effect and gastroprotective mechanisms of 3,5-diprenyl-4-hydroxyacetophenone from Ageratina pichinchensis
AU - Sánchez-Mendoza, María Elena
AU - Rodríguez-Silverio, Juan
AU - Rivero-Cruz, José Fausto
AU - Rocha-González, Héctor Isaac
AU - Pineda-Farías, Jorge Baruch
AU - Arrieta, Jesús
N1 - Funding Information:
This work was supported by two grants from the Escuela Superior de Medicina of the Instituto Politécnico Nacional, México ( SIP 20121158 and SIP 20121254 ).
PY - 2013/6
Y1 - 2013/6
N2 - The present study aimed to evaluate the antinociceptive activity (in inflammatory and neuropathic pain models) and gastroprotective effect of the 3,5-diprenyl-4-hydroxyacetophenone (HYDP), isolated from Ageratina pichinchensis. The gastroprotective activity of this plant was previously reported by our workgroup, finding encesanescin to be one active compound. The present results show that HYDP reduced nociception in a dose-dependent manner in carrageenan and L5/L6 spinal nerve ligation, with efficacies of 72.6 and 57.1%, respectively, at doses of 100 and 562 mg/kg. HYDP also showed gastroprotective activity in the model of ethanol-induced gastric lesion, with a 75.59% maximum inhibition of ulcers at a dose of 100 mg/kg. This gastroprotective effect was attenuated by NG-nitro-l-arginine methyl ester, indomethacin and N-ethylmaleimide, indicating that NO, prostaglandins and sulfhydryl groups are involved in the mechanisms of action. This is the first evidence, to our knowledge, of the antinociceptive and gastroprotective activities of HYDP.
AB - The present study aimed to evaluate the antinociceptive activity (in inflammatory and neuropathic pain models) and gastroprotective effect of the 3,5-diprenyl-4-hydroxyacetophenone (HYDP), isolated from Ageratina pichinchensis. The gastroprotective activity of this plant was previously reported by our workgroup, finding encesanescin to be one active compound. The present results show that HYDP reduced nociception in a dose-dependent manner in carrageenan and L5/L6 spinal nerve ligation, with efficacies of 72.6 and 57.1%, respectively, at doses of 100 and 562 mg/kg. HYDP also showed gastroprotective activity in the model of ethanol-induced gastric lesion, with a 75.59% maximum inhibition of ulcers at a dose of 100 mg/kg. This gastroprotective effect was attenuated by NG-nitro-l-arginine methyl ester, indomethacin and N-ethylmaleimide, indicating that NO, prostaglandins and sulfhydryl groups are involved in the mechanisms of action. This is the first evidence, to our knowledge, of the antinociceptive and gastroprotective activities of HYDP.
KW - 3,5-Diprenyl-4-hydroxyacetophenone
KW - Ageratina pichinchensis
KW - Gastroprotection
KW - Inflammatory pain
KW - Neuropathic pain
UR - http://www.scopus.com/inward/record.url?scp=84878054884&partnerID=8YFLogxK
U2 - 10.1016/j.fitote.2013.03.015
DO - 10.1016/j.fitote.2013.03.015
M3 - Artículo
C2 - 23529015
SN - 0367-326X
VL - 87
SP - 11
EP - 19
JO - Fitoterapia
JF - Fitoterapia
IS - 1
ER -