TY - JOUR
T1 - Antihypertensive, antidyslipidemic, and renoprotective effects of Bursera simaruba on metabolic syndrome
AU - Hernández, Elizabeth Alejandrina Guzmán
AU - Cobos, David Segura
AU - del Rosario González Valle, María
AU - del Carmen Benítez Flores, José
AU - Chávez, Rubén San Miguel
AU - del Valle Mondragón, Leonardo
AU - Guerrero, Gil Alfonso Magos
AU - López Sánchez, Pedro
N1 - Publisher Copyright:
© 2023 Mashhad University of Medical Sciences. All rights reserved.
PY - 2023/4
Y1 - 2023/4
N2 - Objective(s): Metabolic syndrome is associated with the development of chronic kidney disease. Bursera simaruba “chaca” is a medicinal plant used in Mexico for hypertension and empirical therapy. In this study, were examined the effects of ethanol extract of B. simaruba on metabolic syndrome. Materials and Methods: For induction of metabolic syndrome, 20% fructose was used, and it was administered in the water and food to male Wistar rats for 12 weeks, after administering ethanol extract of B. simaruba intragastrically (100 and 200 mg/kg/day) for 6 weeks, blood pressure was determined. In plasma, glucose, cholesterol, triglycerides, angiotensin II, oxide nitric, and angiotensin 1-7 were quantified. In the kidney was performed histological study and the activity of anti-oxidant enzymes was quantified. Results: Rats with metabolic syndrome developed obesity, arterial hypertension, dyslipidemia, and kidney damage characterized by proliferative glomerulonephritis, necrosis, and reduced activity of anti-oxidant enzymes. These alterations were significantly ameliorated by ethanol extract of B. simaruba. Conclusion: The ethanolic extract of B. simaruba showed antidyslipidemic, antihypertensive, antioxidant, and renoprotective effects.
AB - Objective(s): Metabolic syndrome is associated with the development of chronic kidney disease. Bursera simaruba “chaca” is a medicinal plant used in Mexico for hypertension and empirical therapy. In this study, were examined the effects of ethanol extract of B. simaruba on metabolic syndrome. Materials and Methods: For induction of metabolic syndrome, 20% fructose was used, and it was administered in the water and food to male Wistar rats for 12 weeks, after administering ethanol extract of B. simaruba intragastrically (100 and 200 mg/kg/day) for 6 weeks, blood pressure was determined. In plasma, glucose, cholesterol, triglycerides, angiotensin II, oxide nitric, and angiotensin 1-7 were quantified. In the kidney was performed histological study and the activity of anti-oxidant enzymes was quantified. Results: Rats with metabolic syndrome developed obesity, arterial hypertension, dyslipidemia, and kidney damage characterized by proliferative glomerulonephritis, necrosis, and reduced activity of anti-oxidant enzymes. These alterations were significantly ameliorated by ethanol extract of B. simaruba. Conclusion: The ethanolic extract of B. simaruba showed antidyslipidemic, antihypertensive, antioxidant, and renoprotective effects.
KW - Blood pressure
KW - Bursera simaruba
KW - Hyperlipidemia
KW - Kidney failure
KW - Metabolic syndrome
KW - Obesity
KW - Oxidative stress
KW - ►Please cite this article as
UR - http://www.scopus.com/inward/record.url?scp=85153239561&partnerID=8YFLogxK
U2 - 10.22038/IJBMS.2023.66530.14601
DO - 10.22038/IJBMS.2023.66530.14601
M3 - Artículo
C2 - 37009005
AN - SCOPUS:85153239561
SN - 2008-3866
VL - 26
SP - 414
EP - 419
JO - Iranian Journal of Basic Medical Sciences
JF - Iranian Journal of Basic Medical Sciences
IS - 4
ER -