Antihyperalgesia induced by Heliopsis longipes extract

Mario I. Ortiz, Raquel Cariño-Cortés, Nury Pérez-Hernández, Héctor Ponce-Monter, Eduardo Fernández-Martínez, Gilberto Castañeda-Hernández, Iliana I. Acosta-Madrid, Virginia G. Cilia-López

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Heliopsis longipes is an herbaceous plant found in Mexico. Heliopsis longipes is traditionally used for its analgesic and anesthetic properties. Plant extracts may represent a therapeutic advantage for the clinical treatment of pain. Therefore, the main objective of this study was to determine the possible antihyperalgesic effect produced by the Heliopsis longipes ethanolic extract (HLEE) in the Hargreaves model of thermal hyperalgesia in the mouse. HLEE was administrated systemically to mice and the antihyperalgesic effect was evaluated using the thermal hyperalgesia test. Oral Administration of HLEE produced a dose-dependent antihyperalgesic effect. Previously, it was reported that Heliopsis longipes extract was able to release GABA in mice temporal cortex slices. Therefore, it is likely that the antihyperalgesic effect observed in our study could result from GABA liberation and its inhibition of excessive excitation of nociceptive circuits in the thalamus and cortex evoked by tissue injury. Our results suggest that HLEE may represent a therapeutic advantage for the clinical treatment of inflammatory pain.
Original languageAmerican English
Pages (from-to)75-77
Number of pages67
JournalProceedings of the Western Pharmacology Society
StatePublished - 1 Dec 2009
Externally publishedYes

Fingerprint

mice
pain
cortexes
Hyperalgesia
gamma-Aminobutyric Acid
thalamus
anesthetics
Pain
Plant Extracts
Mexico
Temporal Lobe
Therapeutics
Thalamus
Oral Administration
Analgesics
Anesthetics
dosage
Wounds and Injuries
excitation
Inhibition (Psychology)

Cite this

Ortiz, M. I., Cariño-Cortés, R., Pérez-Hernández, N., Ponce-Monter, H., Fernández-Martínez, E., Castañeda-Hernández, G., ... Cilia-López, V. G. (2009). Antihyperalgesia induced by Heliopsis longipes extract. Proceedings of the Western Pharmacology Society, 75-77.
Ortiz, Mario I. ; Cariño-Cortés, Raquel ; Pérez-Hernández, Nury ; Ponce-Monter, Héctor ; Fernández-Martínez, Eduardo ; Castañeda-Hernández, Gilberto ; Acosta-Madrid, Iliana I. ; Cilia-López, Virginia G. / Antihyperalgesia induced by Heliopsis longipes extract. In: Proceedings of the Western Pharmacology Society. 2009 ; pp. 75-77.
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abstract = "Heliopsis longipes is an herbaceous plant found in Mexico. Heliopsis longipes is traditionally used for its analgesic and anesthetic properties. Plant extracts may represent a therapeutic advantage for the clinical treatment of pain. Therefore, the main objective of this study was to determine the possible antihyperalgesic effect produced by the Heliopsis longipes ethanolic extract (HLEE) in the Hargreaves model of thermal hyperalgesia in the mouse. HLEE was administrated systemically to mice and the antihyperalgesic effect was evaluated using the thermal hyperalgesia test. Oral Administration of HLEE produced a dose-dependent antihyperalgesic effect. Previously, it was reported that Heliopsis longipes extract was able to release GABA in mice temporal cortex slices. Therefore, it is likely that the antihyperalgesic effect observed in our study could result from GABA liberation and its inhibition of excessive excitation of nociceptive circuits in the thalamus and cortex evoked by tissue injury. Our results suggest that HLEE may represent a therapeutic advantage for the clinical treatment of inflammatory pain.",
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Ortiz, MI, Cariño-Cortés, R, Pérez-Hernández, N, Ponce-Monter, H, Fernández-Martínez, E, Castañeda-Hernández, G, Acosta-Madrid, II & Cilia-López, VG 2009, 'Antihyperalgesia induced by Heliopsis longipes extract', Proceedings of the Western Pharmacology Society, pp. 75-77.

Antihyperalgesia induced by Heliopsis longipes extract. / Ortiz, Mario I.; Cariño-Cortés, Raquel; Pérez-Hernández, Nury; Ponce-Monter, Héctor; Fernández-Martínez, Eduardo; Castañeda-Hernández, Gilberto; Acosta-Madrid, Iliana I.; Cilia-López, Virginia G.

In: Proceedings of the Western Pharmacology Society, 01.12.2009, p. 75-77.

Research output: Contribution to journalArticleResearchpeer-review

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Ortiz MI, Cariño-Cortés R, Pérez-Hernández N, Ponce-Monter H, Fernández-Martínez E, Castañeda-Hernández G et al. Antihyperalgesia induced by Heliopsis longipes extract. Proceedings of the Western Pharmacology Society. 2009 Dec 1;75-77.