Antihyperalgesia induced by Heliopsis longipes extract

Mario I. Ortiz, Raquel Cariño-Cortés, Nury Pérez-Hernández, Héctor Ponce-Monter, Eduardo Fernández-Martínez, Gilberto Castañeda-Hernández, Iliana I. Acosta-Madrid, Virginia G. Cilia-López

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Heliopsis longipes is an herbaceous plant found in Mexico. Heliopsis longipes is traditionally used for its analgesic and anesthetic properties. Plant extracts may represent a therapeutic advantage for the clinical treatment of pain. Therefore, the main objective of this study was to determine the possible antihyperalgesic effect produced by the Heliopsis longipes ethanolic extract (HLEE) in the Hargreaves model of thermal hyperalgesia in the mouse. HLEE was administrated systemically to mice and the antihyperalgesic effect was evaluated using the thermal hyperalgesia test. Oral Administration of HLEE produced a dose-dependent antihyperalgesic effect. Previously, it was reported that Heliopsis longipes extract was able to release GABA in mice temporal cortex slices. Therefore, it is likely that the antihyperalgesic effect observed in our study could result from GABA liberation and its inhibition of excessive excitation of nociceptive circuits in the thalamus and cortex evoked by tissue injury. Our results suggest that HLEE may represent a therapeutic advantage for the clinical treatment of inflammatory pain.

Original languageEnglish
Pages (from-to)75-77
Number of pages3
JournalProceedings of the Western Pharmacology Society
Volume52
StatePublished - 2009
Externally publishedYes

Fingerprint

Dive into the research topics of 'Antihyperalgesia induced by Heliopsis longipes extract'. Together they form a unique fingerprint.

Cite this