Antigenotoxic studies of different substances to reduce the DNA damage induced by aflatoxin B <inf>1</inf> and ochratoxin A

Eduardo Madrigal-Santillán, José A. Morales-González, Nancy Vargas-Mendoza, Patricia Reyes-Ramírez, Sandra Cruz-Jaime, Teresa Sumaya-Martínez, Ricardo Pérez-Pastén, Eduardo Madrigal-Bujaidar

Research output: Contribution to journalScientific reviewResearchpeer-review

19 Citations (Scopus)

Abstract

Mycotoxins are produced mainly by the mycelial structure of filamentous fungi, or more specifically, molds. These secondary metabolites are synthesized during the end of the exponential growth phase and appear to have no biochemical significance in fungal growth and development. The contamination of foods and feeds with mycotoxins is a significant problem for the adverse effects on humans, animals, and crops that result in illnesses and economic losses. The toxic effect of the ingestion of mycotoxins in humans and animals depends on a number of factors including intake levels, duration of exposure, toxin species, mechanisms of action, metabolism, and defense mechanisms. In general, the consumption of contaminated food and feed with mycotoxin induces to neurotoxic, immunosuppressive, teratogenic, mutagenic, and carcinogenic effect in humans and/or animals. The most significant mycotoxins in terms of public health and agronomic perspective include the aflatoxins, ochratoxin A (OTA), trichothecenes, fumonisins, patulin, and the ergot alkaloids. Due to the detrimental effects of these mycotoxins, several strategies have been developed in order to reduce the risk of exposure. These include the degradation, destruction, inactivation or removal of mycotoxins through chemical, physical and biological methods. However, the results obtained with these methods have not been optimal, because they may change the organoleptic characteristics and nutritional values of food. Another alternative strategy to prevent or reduce the toxic effects of mycotoxins is by applying antimutagenic agents. These substances act according to several extra- or intracellular mechanisms, their main goal being to avoid the interaction of mycotoxins with DNA; as a consequence of their action, these agents would inhibit mutagenesis and carcinogenesis. This article reviews the main strategies used to control AFB 1 and ochratoxin A and contains an analysis of some antigenotoxic substances that reduce the DNA damage caused by these mycotoxins. © 2010 by the authors; licensee MDPI, Basel, Switzerland.
Original languageAmerican English
Pages (from-to)738-757
Number of pages20
JournalToxins
DOIs
StatePublished - 1 Apr 2010

Fingerprint

Aflatoxin B1
Mycotoxins
DNA Damage
DNA
Animals
Poisons
Fungi
Patulin
Antimutagenic Agents
ochratoxin A
Ergot Alkaloids
Trichothecenes
Food Contamination
Fumonisins
Food
Mutagenesis
Aflatoxins
Nutritive Value
Molds
Public health

Cite this

@article{ef37db8488d742359765eb46477fd8f6,
title = "Antigenotoxic studies of different substances to reduce the DNA damage induced by aflatoxin B 1 and ochratoxin A",
abstract = "Mycotoxins are produced mainly by the mycelial structure of filamentous fungi, or more specifically, molds. These secondary metabolites are synthesized during the end of the exponential growth phase and appear to have no biochemical significance in fungal growth and development. The contamination of foods and feeds with mycotoxins is a significant problem for the adverse effects on humans, animals, and crops that result in illnesses and economic losses. The toxic effect of the ingestion of mycotoxins in humans and animals depends on a number of factors including intake levels, duration of exposure, toxin species, mechanisms of action, metabolism, and defense mechanisms. In general, the consumption of contaminated food and feed with mycotoxin induces to neurotoxic, immunosuppressive, teratogenic, mutagenic, and carcinogenic effect in humans and/or animals. The most significant mycotoxins in terms of public health and agronomic perspective include the aflatoxins, ochratoxin A (OTA), trichothecenes, fumonisins, patulin, and the ergot alkaloids. Due to the detrimental effects of these mycotoxins, several strategies have been developed in order to reduce the risk of exposure. These include the degradation, destruction, inactivation or removal of mycotoxins through chemical, physical and biological methods. However, the results obtained with these methods have not been optimal, because they may change the organoleptic characteristics and nutritional values of food. Another alternative strategy to prevent or reduce the toxic effects of mycotoxins is by applying antimutagenic agents. These substances act according to several extra- or intracellular mechanisms, their main goal being to avoid the interaction of mycotoxins with DNA; as a consequence of their action, these agents would inhibit mutagenesis and carcinogenesis. This article reviews the main strategies used to control AFB 1 and ochratoxin A and contains an analysis of some antigenotoxic substances that reduce the DNA damage caused by these mycotoxins. {\circledC} 2010 by the authors; licensee MDPI, Basel, Switzerland.",
author = "Eduardo Madrigal-Santill{\'a}n and Morales-Gonz{\'a}lez, {Jos{\'e} A.} and Nancy Vargas-Mendoza and Patricia Reyes-Ram{\'i}rez and Sandra Cruz-Jaime and Teresa Sumaya-Mart{\'i}nez and Ricardo P{\'e}rez-Past{\'e}n and Eduardo Madrigal-Bujaidar",
year = "2010",
month = "4",
day = "1",
doi = "10.3390/toxins2040738",
language = "American English",
pages = "738--757",
journal = "Toxins",
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}

Antigenotoxic studies of different substances to reduce the DNA damage induced by aflatoxin B <inf>1</inf> and ochratoxin A. / Madrigal-Santillán, Eduardo; Morales-González, José A.; Vargas-Mendoza, Nancy; Reyes-Ramírez, Patricia; Cruz-Jaime, Sandra; Sumaya-Martínez, Teresa; Pérez-Pastén, Ricardo; Madrigal-Bujaidar, Eduardo.

In: Toxins, 01.04.2010, p. 738-757.

Research output: Contribution to journalScientific reviewResearchpeer-review

TY - JOUR

T1 - Antigenotoxic studies of different substances to reduce the DNA damage induced by aflatoxin B 1 and ochratoxin A

AU - Madrigal-Santillán, Eduardo

AU - Morales-González, José A.

AU - Vargas-Mendoza, Nancy

AU - Reyes-Ramírez, Patricia

AU - Cruz-Jaime, Sandra

AU - Sumaya-Martínez, Teresa

AU - Pérez-Pastén, Ricardo

AU - Madrigal-Bujaidar, Eduardo

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Mycotoxins are produced mainly by the mycelial structure of filamentous fungi, or more specifically, molds. These secondary metabolites are synthesized during the end of the exponential growth phase and appear to have no biochemical significance in fungal growth and development. The contamination of foods and feeds with mycotoxins is a significant problem for the adverse effects on humans, animals, and crops that result in illnesses and economic losses. The toxic effect of the ingestion of mycotoxins in humans and animals depends on a number of factors including intake levels, duration of exposure, toxin species, mechanisms of action, metabolism, and defense mechanisms. In general, the consumption of contaminated food and feed with mycotoxin induces to neurotoxic, immunosuppressive, teratogenic, mutagenic, and carcinogenic effect in humans and/or animals. The most significant mycotoxins in terms of public health and agronomic perspective include the aflatoxins, ochratoxin A (OTA), trichothecenes, fumonisins, patulin, and the ergot alkaloids. Due to the detrimental effects of these mycotoxins, several strategies have been developed in order to reduce the risk of exposure. These include the degradation, destruction, inactivation or removal of mycotoxins through chemical, physical and biological methods. However, the results obtained with these methods have not been optimal, because they may change the organoleptic characteristics and nutritional values of food. Another alternative strategy to prevent or reduce the toxic effects of mycotoxins is by applying antimutagenic agents. These substances act according to several extra- or intracellular mechanisms, their main goal being to avoid the interaction of mycotoxins with DNA; as a consequence of their action, these agents would inhibit mutagenesis and carcinogenesis. This article reviews the main strategies used to control AFB 1 and ochratoxin A and contains an analysis of some antigenotoxic substances that reduce the DNA damage caused by these mycotoxins. © 2010 by the authors; licensee MDPI, Basel, Switzerland.

AB - Mycotoxins are produced mainly by the mycelial structure of filamentous fungi, or more specifically, molds. These secondary metabolites are synthesized during the end of the exponential growth phase and appear to have no biochemical significance in fungal growth and development. The contamination of foods and feeds with mycotoxins is a significant problem for the adverse effects on humans, animals, and crops that result in illnesses and economic losses. The toxic effect of the ingestion of mycotoxins in humans and animals depends on a number of factors including intake levels, duration of exposure, toxin species, mechanisms of action, metabolism, and defense mechanisms. In general, the consumption of contaminated food and feed with mycotoxin induces to neurotoxic, immunosuppressive, teratogenic, mutagenic, and carcinogenic effect in humans and/or animals. The most significant mycotoxins in terms of public health and agronomic perspective include the aflatoxins, ochratoxin A (OTA), trichothecenes, fumonisins, patulin, and the ergot alkaloids. Due to the detrimental effects of these mycotoxins, several strategies have been developed in order to reduce the risk of exposure. These include the degradation, destruction, inactivation or removal of mycotoxins through chemical, physical and biological methods. However, the results obtained with these methods have not been optimal, because they may change the organoleptic characteristics and nutritional values of food. Another alternative strategy to prevent or reduce the toxic effects of mycotoxins is by applying antimutagenic agents. These substances act according to several extra- or intracellular mechanisms, their main goal being to avoid the interaction of mycotoxins with DNA; as a consequence of their action, these agents would inhibit mutagenesis and carcinogenesis. This article reviews the main strategies used to control AFB 1 and ochratoxin A and contains an analysis of some antigenotoxic substances that reduce the DNA damage caused by these mycotoxins. © 2010 by the authors; licensee MDPI, Basel, Switzerland.

U2 - 10.3390/toxins2040738

DO - 10.3390/toxins2040738

M3 - Scientific review

SP - 738

EP - 757

JO - Toxins

JF - Toxins

SN - 2072-6651

ER -