TY - JOUR
T1 - Antidepressant-like effects of a methanol extract of Leonotis nepetifolia in mice
AU - Arrieta-Báez, Daniel
AU - Gómez-Patiño, Mayra Beatriz
AU - Jurado Hernández, Noé
AU - Mayagoitia-Novales, Lilian
AU - Dorantes-Barrón, Ana María
AU - Estrada-Reyes, Rosa
N1 - Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - This study evaluated the antidepressant-like effects of a methanol extract of Leonotis nepetifolia in behavioural tests in mice. Our results showed that a single administration of the extract significantly reduced immobility behaviour in the tail suspension test, while three administrations were necessary to diminish immobility behaviour in the forced swimming test. A daily dose of the extract for 28 days improved body weight gain and significantly reduced corticosterone levels of mice exposed to chronic unpredictable mild stress. Metabolic profiling of the extract revealed that nepetaefolin, methoxynepataefolin, and 7-O-β-glucoside luteolin were the main products. Acute and repeated administration of the extract produced antidepressant-like effects in animals subjected to chronic stress. Our results suggest the hypothalamus-hypophysis-adrenal axis participates in the antidepressant actions of the extract. These results show that alterations in behaviour elicited by stress can be prevented with L. nepetifolia treatment.
AB - This study evaluated the antidepressant-like effects of a methanol extract of Leonotis nepetifolia in behavioural tests in mice. Our results showed that a single administration of the extract significantly reduced immobility behaviour in the tail suspension test, while three administrations were necessary to diminish immobility behaviour in the forced swimming test. A daily dose of the extract for 28 days improved body weight gain and significantly reduced corticosterone levels of mice exposed to chronic unpredictable mild stress. Metabolic profiling of the extract revealed that nepetaefolin, methoxynepataefolin, and 7-O-β-glucoside luteolin were the main products. Acute and repeated administration of the extract produced antidepressant-like effects in animals subjected to chronic stress. Our results suggest the hypothalamus-hypophysis-adrenal axis participates in the antidepressant actions of the extract. These results show that alterations in behaviour elicited by stress can be prevented with L. nepetifolia treatment.
KW - Leonotis nepetifolia
KW - antidepressant
KW - chronic stress
KW - methoxynepataefolin
KW - nepetaefolin
UR - http://www.scopus.com/inward/record.url?scp=85128174188&partnerID=8YFLogxK
U2 - 10.1080/14786419.2022.2058939
DO - 10.1080/14786419.2022.2058939
M3 - Artículo
C2 - 35357257
AN - SCOPUS:85128174188
SN - 1478-6419
VL - 36
SP - 6170
EP - 6176
JO - Natural Product Research
JF - Natural Product Research
IS - 23
ER -