Anticoagulant proteins in a population of mexican mestizo donors

Luis Antonio Meillón-García, Edgar Hernández-Zamora, Guadalupe Montiel-Manzano, Cesar Zavala-Hernández, Eduardo Ramírez-San Juan, Gabriela Cesarman-Maus, Elba Reyes-Maldonado

Research output: Contribution to journalArticle

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Abstract

Background To determine the activity of antithrombin (AT), protein C (PC), and protein S (PS), as well as the frequency of deficiencies of these proteins in a population of healthy Mexican mestizo blood donors. Methods AT, PC, and PS were determined from 1,502 plasma samples of healthy blood donors by using commercial kits in a coagulometer 4 STA (Diagnostica Stago, Asnières, France). Results A total of 741 women and 761 men were under study. They were divided into age range groups (18-24, 25-34, 35-44, 45-54, and 55-64 years). Activity of AT, PC, and PS was determined. For AT, activity values were specific for each age group according to gender when it had to do with PS, as well as when PC was determined. Frequencies of AT, PC, PS, and activated PC resistance activity deficiencies were obtained from reference levels (RLs) and average levels of this study. Differences were found between both frequencies for AT, PC, and PS, and the average levels obtained were used in this study. The frequencies of the activity deficiencies obtained through the values gotten in this population were: AT, 0.6%; PC, 1.06% (which is higher than the one obtained using the RLs described by commercial kits 0.33% and 0.66%, respectively); and PS, 1% (which is less than 4.5%). Conclusions It is necessary to know the characteristics and biological behavior of the coagulation proteins in the Mexican population because the RLs used have been established for populations that are genetically different.

Original languageEnglish
Pages (from-to)222-226
Number of pages5
JournalAnnals of Vascular Surgery
Volume29
Issue number2
DOIs
StatePublished - 1 Feb 2015

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Protein S
Antithrombin Proteins
Protein C
Anticoagulants
Tissue Donors
Population
Proteins
Antithrombins
Blood Donors
Age Groups
Activated Protein C Resistance
Protein Deficiency
France

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Meillón-García, L. A., Hernández-Zamora, E., Montiel-Manzano, G., Zavala-Hernández, C., Ramírez-San Juan, E., Cesarman-Maus, G., & Reyes-Maldonado, E. (2015). Anticoagulant proteins in a population of mexican mestizo donors. Annals of Vascular Surgery, 29(2), 222-226. https://doi.org/10.1016/j.avsg.2014.09.023
Meillón-García, Luis Antonio ; Hernández-Zamora, Edgar ; Montiel-Manzano, Guadalupe ; Zavala-Hernández, Cesar ; Ramírez-San Juan, Eduardo ; Cesarman-Maus, Gabriela ; Reyes-Maldonado, Elba. / Anticoagulant proteins in a population of mexican mestizo donors. In: Annals of Vascular Surgery. 2015 ; Vol. 29, No. 2. pp. 222-226.
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title = "Anticoagulant proteins in a population of mexican mestizo donors",
abstract = "Background To determine the activity of antithrombin (AT), protein C (PC), and protein S (PS), as well as the frequency of deficiencies of these proteins in a population of healthy Mexican mestizo blood donors. Methods AT, PC, and PS were determined from 1,502 plasma samples of healthy blood donors by using commercial kits in a coagulometer 4 STA (Diagnostica Stago, Asni{\`e}res, France). Results A total of 741 women and 761 men were under study. They were divided into age range groups (18-24, 25-34, 35-44, 45-54, and 55-64 years). Activity of AT, PC, and PS was determined. For AT, activity values were specific for each age group according to gender when it had to do with PS, as well as when PC was determined. Frequencies of AT, PC, PS, and activated PC resistance activity deficiencies were obtained from reference levels (RLs) and average levels of this study. Differences were found between both frequencies for AT, PC, and PS, and the average levels obtained were used in this study. The frequencies of the activity deficiencies obtained through the values gotten in this population were: AT, 0.6{\%}; PC, 1.06{\%} (which is higher than the one obtained using the RLs described by commercial kits 0.33{\%} and 0.66{\%}, respectively); and PS, 1{\%} (which is less than 4.5{\%}). Conclusions It is necessary to know the characteristics and biological behavior of the coagulation proteins in the Mexican population because the RLs used have been established for populations that are genetically different.",
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Meillón-García, LA, Hernández-Zamora, E, Montiel-Manzano, G, Zavala-Hernández, C, Ramírez-San Juan, E, Cesarman-Maus, G & Reyes-Maldonado, E 2015, 'Anticoagulant proteins in a population of mexican mestizo donors', Annals of Vascular Surgery, vol. 29, no. 2, pp. 222-226. https://doi.org/10.1016/j.avsg.2014.09.023

Anticoagulant proteins in a population of mexican mestizo donors. / Meillón-García, Luis Antonio; Hernández-Zamora, Edgar; Montiel-Manzano, Guadalupe; Zavala-Hernández, Cesar; Ramírez-San Juan, Eduardo; Cesarman-Maus, Gabriela; Reyes-Maldonado, Elba.

In: Annals of Vascular Surgery, Vol. 29, No. 2, 01.02.2015, p. 222-226.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Anticoagulant proteins in a population of mexican mestizo donors

AU - Meillón-García, Luis Antonio

AU - Hernández-Zamora, Edgar

AU - Montiel-Manzano, Guadalupe

AU - Zavala-Hernández, Cesar

AU - Ramírez-San Juan, Eduardo

AU - Cesarman-Maus, Gabriela

AU - Reyes-Maldonado, Elba

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Background To determine the activity of antithrombin (AT), protein C (PC), and protein S (PS), as well as the frequency of deficiencies of these proteins in a population of healthy Mexican mestizo blood donors. Methods AT, PC, and PS were determined from 1,502 plasma samples of healthy blood donors by using commercial kits in a coagulometer 4 STA (Diagnostica Stago, Asnières, France). Results A total of 741 women and 761 men were under study. They were divided into age range groups (18-24, 25-34, 35-44, 45-54, and 55-64 years). Activity of AT, PC, and PS was determined. For AT, activity values were specific for each age group according to gender when it had to do with PS, as well as when PC was determined. Frequencies of AT, PC, PS, and activated PC resistance activity deficiencies were obtained from reference levels (RLs) and average levels of this study. Differences were found between both frequencies for AT, PC, and PS, and the average levels obtained were used in this study. The frequencies of the activity deficiencies obtained through the values gotten in this population were: AT, 0.6%; PC, 1.06% (which is higher than the one obtained using the RLs described by commercial kits 0.33% and 0.66%, respectively); and PS, 1% (which is less than 4.5%). Conclusions It is necessary to know the characteristics and biological behavior of the coagulation proteins in the Mexican population because the RLs used have been established for populations that are genetically different.

AB - Background To determine the activity of antithrombin (AT), protein C (PC), and protein S (PS), as well as the frequency of deficiencies of these proteins in a population of healthy Mexican mestizo blood donors. Methods AT, PC, and PS were determined from 1,502 plasma samples of healthy blood donors by using commercial kits in a coagulometer 4 STA (Diagnostica Stago, Asnières, France). Results A total of 741 women and 761 men were under study. They were divided into age range groups (18-24, 25-34, 35-44, 45-54, and 55-64 years). Activity of AT, PC, and PS was determined. For AT, activity values were specific for each age group according to gender when it had to do with PS, as well as when PC was determined. Frequencies of AT, PC, PS, and activated PC resistance activity deficiencies were obtained from reference levels (RLs) and average levels of this study. Differences were found between both frequencies for AT, PC, and PS, and the average levels obtained were used in this study. The frequencies of the activity deficiencies obtained through the values gotten in this population were: AT, 0.6%; PC, 1.06% (which is higher than the one obtained using the RLs described by commercial kits 0.33% and 0.66%, respectively); and PS, 1% (which is less than 4.5%). Conclusions It is necessary to know the characteristics and biological behavior of the coagulation proteins in the Mexican population because the RLs used have been established for populations that are genetically different.

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U2 - 10.1016/j.avsg.2014.09.023

DO - 10.1016/j.avsg.2014.09.023

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Meillón-García LA, Hernández-Zamora E, Montiel-Manzano G, Zavala-Hernández C, Ramírez-San Juan E, Cesarman-Maus G et al. Anticoagulant proteins in a population of mexican mestizo donors. Annals of Vascular Surgery. 2015 Feb 1;29(2):222-226. https://doi.org/10.1016/j.avsg.2014.09.023