TY - JOUR
T1 - Antibacterial proteins and peptides as potential treatment in aquaculture
T2 - current status and perspectives on delivery
AU - Zermeño-Cervantes, Lina Angélica
AU - González-Acosta, Bárbara
AU - Martínez-Díaz, Sergio Francisco
AU - Cardona-Félix, César Salvador
N1 - Publisher Copyright:
© 2019 Wiley Publishing Asia Pty Ltd
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Although aquaculture is a growing productive sector, economic losses because of infectious diseases and public health concern of what antibiotic resistance represents have become factors that limit its development. Thus, the control of infectious diseases through antibacterial alternatives is a field of intense research. In this sense, antimicrobial proteins and peptides might represent a safe and effective alternative because their site of action is on microbial components; they are biodegradable; their diversity in terms of mechanisms of action is broad; and some of them can be highly specific. Because this antibacterial alternative is still in research, this review provides a critical analysis of the challenges and opportunities of protein drugs for the treatment of bacterial diseases in the field of aquaculture health; contextualizes the different types of antibacterial protein and peptides, their mechanisms of action, potential sources, as well as the state of the art on assessment of antibacterial proteins and peptides in bioassays with aquatic organisms; and discusses the challenges proteinaceous drugs face regarding their stability for oral delivery and the perspectives for their administration in aquaculture.
AB - Although aquaculture is a growing productive sector, economic losses because of infectious diseases and public health concern of what antibiotic resistance represents have become factors that limit its development. Thus, the control of infectious diseases through antibacterial alternatives is a field of intense research. In this sense, antimicrobial proteins and peptides might represent a safe and effective alternative because their site of action is on microbial components; they are biodegradable; their diversity in terms of mechanisms of action is broad; and some of them can be highly specific. Because this antibacterial alternative is still in research, this review provides a critical analysis of the challenges and opportunities of protein drugs for the treatment of bacterial diseases in the field of aquaculture health; contextualizes the different types of antibacterial protein and peptides, their mechanisms of action, potential sources, as well as the state of the art on assessment of antibacterial proteins and peptides in bioassays with aquatic organisms; and discusses the challenges proteinaceous drugs face regarding their stability for oral delivery and the perspectives for their administration in aquaculture.
KW - aquaculture health management
KW - environmentally friendly alternatives
KW - enzybiotics
KW - in vivo evaluations
KW - protein stability
KW - proteinaceous drugs
UR - http://www.scopus.com/inward/record.url?scp=85070670672&partnerID=8YFLogxK
U2 - 10.1111/raq.12376
DO - 10.1111/raq.12376
M3 - Artículo de revisión
AN - SCOPUS:85070670672
SN - 1753-5123
VL - 12
SP - 1135
EP - 1156
JO - Reviews in Aquaculture
JF - Reviews in Aquaculture
IS - 2
ER -