Antiamoebic activity of benzyl glucosinolate from Lepidium virginicum

Fernando Calzada, Elizabeth Barbosa, Roberto Cedillo-Rivera

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In a continuation of our search for potential antiprotozoal agents from plants, we found that a crude extract from the roots of Lepidium virginicum exhibited antiprotozoal activity against Entamoeba histolytica trophozoites (IC50 of 100.1 μg/mL). Bioassay-guided fractionation resulted in the isolation of one known glucosinolate responsible for such activity. This compound was identified as benzyl glucosinolate. It showed in vitro activity against Entamoeba histolytica strain HM1-IMSS (IC50 of 20.4 μg/mL). The results support the anecdotal reports for the traditional use of L. virginicum roots in the control of diarrhoea and dysentery in the highlands of Chiapas, Mexico. Copyright © 2003 John Wiley & Sons, Ltd.
Original languageAmerican English
Pages (from-to)618-619
Number of pages556
JournalPhytotherapy Research
DOIs
StatePublished - 1 Jun 2003
Externally publishedYes

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Lepidium
Glucosinolates
Entamoeba histolytica
Bioassay
Fractionation
Inhibitory Concentration 50
Antiprotozoal Agents
dysentery
Trophozoites
Dysentery
Mexico
Complex Mixtures
Biological Assay
bioassay
Diarrhea
fractionation

Cite this

Calzada, Fernando ; Barbosa, Elizabeth ; Cedillo-Rivera, Roberto. / Antiamoebic activity of benzyl glucosinolate from Lepidium virginicum. In: Phytotherapy Research. 2003 ; pp. 618-619.
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Antiamoebic activity of benzyl glucosinolate from Lepidium virginicum. / Calzada, Fernando; Barbosa, Elizabeth; Cedillo-Rivera, Roberto.

In: Phytotherapy Research, 01.06.2003, p. 618-619.

Research output: Contribution to journalArticle

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