TY - JOUR
T1 - Anti-neuroinflammatory effect of agaves and cantalasaponin-1 in a model of LPS-induced damage
AU - Herrera-Ruiz, Maribel
AU - Jiménez-Ferrer, Enrique
AU - Tortoriello, Jaime
AU - Zamilpa, Alejandro
AU - Alegría-Herrera, Elian
AU - Jiménez-Aparicio, Antonio R.
AU - Arenas-Ocampo, Martha L.
AU - Martínez-Duncker, Iván
AU - Monterrosas-Brisson, Nayeli
N1 - Publisher Copyright:
© 2019 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Chronic neuroinflammation is a key component of many neurodegenerative disorders. Chronic activation of this process produces pro-inflammatory cytokines, prostaglandins and reactive oxygen species that induce brain injury and neuronal dysfunction. Agave species contain saponins, compounds with anti-inflammatory activity. Extracts from A. tequilana (At), A. angustifolia (Aan), A. Americana (Aam) (125 mg/kg) and cantalasaponin-1 (5 and 10 mg/kg, isolated from Aam) were administered to male ICR mice with lipopolysaccharide (LPS)-induced neuroinflammation, after which inflammatory cytokines were measured in brain homogenates by using an enzyme-linked immunoassay (ELISA) test. All agave extracts and cantalasaponin-1, reduced brain concentration of LPS-induced pro-inflammatory cytokines IL-6 and TNF-α. Moreover, Cantalasaponin-1 increased the brain concentration of the anti-inflammatory cytokine IL-10. Agave extracts and derived compounds show promising results in the development of novel drugs for neuroinflammatory disease therapy.
AB - Chronic neuroinflammation is a key component of many neurodegenerative disorders. Chronic activation of this process produces pro-inflammatory cytokines, prostaglandins and reactive oxygen species that induce brain injury and neuronal dysfunction. Agave species contain saponins, compounds with anti-inflammatory activity. Extracts from A. tequilana (At), A. angustifolia (Aan), A. Americana (Aam) (125 mg/kg) and cantalasaponin-1 (5 and 10 mg/kg, isolated from Aam) were administered to male ICR mice with lipopolysaccharide (LPS)-induced neuroinflammation, after which inflammatory cytokines were measured in brain homogenates by using an enzyme-linked immunoassay (ELISA) test. All agave extracts and cantalasaponin-1, reduced brain concentration of LPS-induced pro-inflammatory cytokines IL-6 and TNF-α. Moreover, Cantalasaponin-1 increased the brain concentration of the anti-inflammatory cytokine IL-10. Agave extracts and derived compounds show promising results in the development of novel drugs for neuroinflammatory disease therapy.
KW - Neuroinflammation
KW - agave
KW - cantalasaponin-1
KW - lipopolysaccharide
UR - http://www.scopus.com/inward/record.url?scp=85065755335&partnerID=8YFLogxK
U2 - 10.1080/14786419.2019.1608537
DO - 10.1080/14786419.2019.1608537
M3 - Artículo
C2 - 31084220
AN - SCOPUS:85065755335
SN - 1478-6419
VL - 35
SP - 884
EP - 887
JO - Natural Product Research
JF - Natural Product Research
IS - 5
ER -