TY - JOUR
T1 - Analysis of the genomic diversity of human papillomavirus type 31 in cervical samples reveals the presence of novel sublineages in clade C
AU - Fragoso-Fonseca, David Esaú
AU - Ruiz-Hernández, Ubaldo Emilio
AU - Trujillo-Salgado, Brenda Berenice
AU - Manuell-Barrios, Rita Teresita
AU - Garcés-Ayala, Fabiola
AU - del Mazo-López, Juan Carlos
AU - Méndez-Tenorio, Alfonso
AU - Hernández-Rivas, Lucía
AU - Ramírez-González, José Ernesto
AU - Escobar-Escamilla, Noé
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
PY - 2022/12
Y1 - 2022/12
N2 - Human papillomavirus 31 (HPV31) is the fourth most frequent high-risk HPV (HR-HPV) genotype identified in cervical cancer (CC) worldwide and in Mexico. It has been recently classified into three lineages (A, B, and C) and eight sublineages (A1, A2, B1, B2, and C1 – C4). Here, we report the complete genomic sequences of 14 HPV31 isolates from cervical samples, and these were compared with viral genome sequences from the GenBank database for phylogenetic and genetic distance analysis. The formation of two novel clades within the C lineage (proposed as C5 and C6) was observed, with a well-defined variant-specific mutational pattern. The smallest average pairwise distance was 0.71% for lineages A and B, 0.94% for lineages A and C, and 1.01% for lineages B and C, and between sublineages, these values were 0.21% for clade A, 0.29% for clade B, and 0.24% for clade C. The isolates were grouped into the sublineages A1, B2, C1-C3, and C6. This is the first report on the whole-genome diversity of HPV31 in Mexico.
AB - Human papillomavirus 31 (HPV31) is the fourth most frequent high-risk HPV (HR-HPV) genotype identified in cervical cancer (CC) worldwide and in Mexico. It has been recently classified into three lineages (A, B, and C) and eight sublineages (A1, A2, B1, B2, and C1 – C4). Here, we report the complete genomic sequences of 14 HPV31 isolates from cervical samples, and these were compared with viral genome sequences from the GenBank database for phylogenetic and genetic distance analysis. The formation of two novel clades within the C lineage (proposed as C5 and C6) was observed, with a well-defined variant-specific mutational pattern. The smallest average pairwise distance was 0.71% for lineages A and B, 0.94% for lineages A and C, and 1.01% for lineages B and C, and between sublineages, these values were 0.21% for clade A, 0.29% for clade B, and 0.24% for clade C. The isolates were grouped into the sublineages A1, B2, C1-C3, and C6. This is the first report on the whole-genome diversity of HPV31 in Mexico.
UR - http://www.scopus.com/inward/record.url?scp=85137775200&partnerID=8YFLogxK
U2 - 10.1007/s00705-022-05589-2
DO - 10.1007/s00705-022-05589-2
M3 - Artículo
C2 - 36085531
AN - SCOPUS:85137775200
SN - 0304-8608
VL - 167
SP - 2795
EP - 2800
JO - Archives of Virology
JF - Archives of Virology
IS - 12
ER -