Analysis of self-reported adverse reactions to efavirenz and drug interactions in a population with HIV in Mexico

María Fernanda Martínez-Salazar, Jesús Oaxaca-Navarro, Alfonso Leija-Salas, Sara García-Jiménez, Miguel Angel Sánchez-Alemán, Myrna Déciga-Campos

Research output: Contribution to journalArticle

Abstract

© European Association of Hospital Pharmacists (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Objective To analyse the most frequent self-reported adverse reactions (ARs), the durability and the causes of antiretrovirals (ARVs) regimens change, concomitant treatments and drug interactions related to the use of ARVs in a group of people living with HIV in Cuernavaca, Morelos, Mexico. Materials and methods Cross-sectional study conducted in a clinic specialising in HIV 'CAPASITS-Cuernavaca' in Mexico from February to June 2015. People who wanted to participate were given a questionnaire on demographic characteristics, adherence, concomitant treatments and ARs. To understand the clinical variables, the clinical records were reviewed. Quantitative variables were compared using Student's t-test for normal data and the Mann-Whitney U test for non-normal data. For comparisons between categorical variables, the χ 2 test was used. All tests used a significance level of 0.05. Results A total of 96 people participated, and 218 ARs (mean= 2.3±1.9) were found. The most frequently encountered ARs were dizziness (53.1%), insomnia (21.9%) and lucid dreams (17.7%). Twenty-three people (24%) were polymedicated, and 18 potential interactions were detected in 12 people. Conclusions The results suggest that a thorough analysis of the possible drug interactions should be performed for polymedicated people on ARV treatment and that a protocol should be designed for the monitoring and management of AR to ensure a good adherence to ARV treatment.
Original languageAmerican English
Pages (from-to)322-326
Number of pages289
JournalEuropean Journal of Hospital Pharmacy
DOIs
StatePublished - 24 Jun 2017

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efavirenz
Mexico
Drug Interactions
HIV
Population
Sleep Initiation and Maintenance Disorders
Dizziness
Clinical Protocols
Nonparametric Statistics
Therapeutics
Cross-Sectional Studies
Demography
Students

Cite this

Martínez-Salazar, María Fernanda ; Oaxaca-Navarro, Jesús ; Leija-Salas, Alfonso ; García-Jiménez, Sara ; Sánchez-Alemán, Miguel Angel ; Déciga-Campos, Myrna. / Analysis of self-reported adverse reactions to efavirenz and drug interactions in a population with HIV in Mexico. In: European Journal of Hospital Pharmacy. 2017 ; pp. 322-326.
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Analysis of self-reported adverse reactions to efavirenz and drug interactions in a population with HIV in Mexico. / Martínez-Salazar, María Fernanda; Oaxaca-Navarro, Jesús; Leija-Salas, Alfonso; García-Jiménez, Sara; Sánchez-Alemán, Miguel Angel; Déciga-Campos, Myrna.

In: European Journal of Hospital Pharmacy, 24.06.2017, p. 322-326.

Research output: Contribution to journalArticle

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AU - Oaxaca-Navarro, Jesús

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AU - García-Jiménez, Sara

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AU - Déciga-Campos, Myrna

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N2 - © European Association of Hospital Pharmacists (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Objective To analyse the most frequent self-reported adverse reactions (ARs), the durability and the causes of antiretrovirals (ARVs) regimens change, concomitant treatments and drug interactions related to the use of ARVs in a group of people living with HIV in Cuernavaca, Morelos, Mexico. Materials and methods Cross-sectional study conducted in a clinic specialising in HIV 'CAPASITS-Cuernavaca' in Mexico from February to June 2015. People who wanted to participate were given a questionnaire on demographic characteristics, adherence, concomitant treatments and ARs. To understand the clinical variables, the clinical records were reviewed. Quantitative variables were compared using Student's t-test for normal data and the Mann-Whitney U test for non-normal data. For comparisons between categorical variables, the χ 2 test was used. All tests used a significance level of 0.05. Results A total of 96 people participated, and 218 ARs (mean= 2.3±1.9) were found. The most frequently encountered ARs were dizziness (53.1%), insomnia (21.9%) and lucid dreams (17.7%). Twenty-three people (24%) were polymedicated, and 18 potential interactions were detected in 12 people. Conclusions The results suggest that a thorough analysis of the possible drug interactions should be performed for polymedicated people on ARV treatment and that a protocol should be designed for the monitoring and management of AR to ensure a good adherence to ARV treatment.

AB - © European Association of Hospital Pharmacists (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Objective To analyse the most frequent self-reported adverse reactions (ARs), the durability and the causes of antiretrovirals (ARVs) regimens change, concomitant treatments and drug interactions related to the use of ARVs in a group of people living with HIV in Cuernavaca, Morelos, Mexico. Materials and methods Cross-sectional study conducted in a clinic specialising in HIV 'CAPASITS-Cuernavaca' in Mexico from February to June 2015. People who wanted to participate were given a questionnaire on demographic characteristics, adherence, concomitant treatments and ARs. To understand the clinical variables, the clinical records were reviewed. Quantitative variables were compared using Student's t-test for normal data and the Mann-Whitney U test for non-normal data. For comparisons between categorical variables, the χ 2 test was used. All tests used a significance level of 0.05. Results A total of 96 people participated, and 218 ARs (mean= 2.3±1.9) were found. The most frequently encountered ARs were dizziness (53.1%), insomnia (21.9%) and lucid dreams (17.7%). Twenty-three people (24%) were polymedicated, and 18 potential interactions were detected in 12 people. Conclusions The results suggest that a thorough analysis of the possible drug interactions should be performed for polymedicated people on ARV treatment and that a protocol should be designed for the monitoring and management of AR to ensure a good adherence to ARV treatment.

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