TY - JOUR
T1 - Analysis of self-reported adverse reactions to efavirenz and drug interactions in a population with HIV in Mexico
AU - Martínez-Salazar, María Fernanda
AU - Oaxaca-Navarro, Jesús
AU - Leija-Salas, Alfonso
AU - García-Jiménez, Sara
AU - Sánchez-Alemán, Miguel Angel
AU - Déciga-Campos, Myrna
N1 - Publisher Copyright:
© European Association of Hospital Pharmacists (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
PY - 2017/6/24
Y1 - 2017/6/24
N2 - Objective To analyse the most frequent self-reported adverse reactions (ARs), the durability and the causes of antiretrovirals (ARVs) regimens change, concomitant treatments and drug interactions related to the use of ARVs in a group of people living with HIV in Cuernavaca, Morelos, Mexico. Materials and methods Cross-sectional study conducted in a clinic specialising in HIV 'CAPASITS-Cuernavaca' in Mexico from February to June 2015. People who wanted to participate were given a questionnaire on demographic characteristics, adherence, concomitant treatments and ARs. To understand the clinical variables, the clinical records were reviewed. Quantitative variables were compared using Student's t-test for normal data and the Mann-Whitney U test for non-normal data. For comparisons between categorical variables, the χ 2 test was used. All tests used a significance level of 0.05. Results A total of 96 people participated, and 218 ARs (mean= 2.3±1.9) were found. The most frequently encountered ARs were dizziness (53.1%), insomnia (21.9%) and lucid dreams (17.7%). Twenty-three people (24%) were polymedicated, and 18 potential interactions were detected in 12 people. Conclusions The results suggest that a thorough analysis of the possible drug interactions should be performed for polymedicated people on ARV treatment and that a protocol should be designed for the monitoring and management of AR to ensure a good adherence to ARV treatment.
AB - Objective To analyse the most frequent self-reported adverse reactions (ARs), the durability and the causes of antiretrovirals (ARVs) regimens change, concomitant treatments and drug interactions related to the use of ARVs in a group of people living with HIV in Cuernavaca, Morelos, Mexico. Materials and methods Cross-sectional study conducted in a clinic specialising in HIV 'CAPASITS-Cuernavaca' in Mexico from February to June 2015. People who wanted to participate were given a questionnaire on demographic characteristics, adherence, concomitant treatments and ARs. To understand the clinical variables, the clinical records were reviewed. Quantitative variables were compared using Student's t-test for normal data and the Mann-Whitney U test for non-normal data. For comparisons between categorical variables, the χ 2 test was used. All tests used a significance level of 0.05. Results A total of 96 people participated, and 218 ARs (mean= 2.3±1.9) were found. The most frequently encountered ARs were dizziness (53.1%), insomnia (21.9%) and lucid dreams (17.7%). Twenty-three people (24%) were polymedicated, and 18 potential interactions were detected in 12 people. Conclusions The results suggest that a thorough analysis of the possible drug interactions should be performed for polymedicated people on ARV treatment and that a protocol should be designed for the monitoring and management of AR to ensure a good adherence to ARV treatment.
KW - HIV
KW - adverse reactions
KW - antiretroviral
KW - drug interactions
KW - polymedication
UR - http://www.scopus.com/inward/record.url?scp=85026673566&partnerID=8YFLogxK
U2 - 10.1136/ejhpharm-2016-001106
DO - 10.1136/ejhpharm-2016-001106
M3 - Artículo
SN - 2047-9956
VL - 25
SP - 322
EP - 326
JO - European Journal of Hospital Pharmacy
JF - European Journal of Hospital Pharmacy
IS - 6
ER -