TY - JOUR
T1 - Analysis by response surface methodology of gold nanoparticles obtained by green chemical reduction using aqueous coffee pulp extract (Coffea arabica)
AU - Bonilla-Nepomuceno, Galileo
AU - Ríos-Corripio, María Antonieta
AU - Gómez-Merino, Fernando C.
AU - Méndez-Rojas, Miguel Ángel
AU - Arcila-Lozano, Leslie Susana
AU - Hernández-Cázares, Aleida Selene
AU - Rojas-López, Marlon
N1 - Publisher Copyright:
© 2021, Canadian Science Publishing. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Green synthesis of gold nanoparticles using an aqueous coffee (Coffea arabica L.) pulp extract as a reducing agent was achieved and analyzed by response surface methodology, given the diverse applicability of these nanoparticles containing a wide range of phenolic compounds from the coffee pulp extract. Three factors (precursor concentration, reducing agent concentration, and reaction time) were considered and their combined effects on the maximum intensity MA, particle size d, and particle density N were analyzed. An opposing effect between the precursor and reducing agent was observed during synthesis, because although the precursor increased d and diminished N, the reducing agent diminished d and increased N. These effects were observed simultaneously through the response surfaces of d and N. This methodology allowed the synthesis of nanoparticles with an average particle size of 5–22 nm and N around 2.9 x 1011 3.7 x 1013 part/mL, depending on the response surface methodology, Box–Behnken design. The R2 value determined for all cases was 0.98 (MA), 0.99 (d), and 0.97 (N), clearly indicating that the model can be used to predict or design the response variables in the design space. Finally, Fourier transform infrared measurements showed that the organic compounds present in the aqueous coffee pulp extract were coating the surface of the gold nanoparticles. The proposed methodology could contribute to the design of new alternatives for the synthesis of specific nanostructures with potential applications in the therapeutic area.
AB - Green synthesis of gold nanoparticles using an aqueous coffee (Coffea arabica L.) pulp extract as a reducing agent was achieved and analyzed by response surface methodology, given the diverse applicability of these nanoparticles containing a wide range of phenolic compounds from the coffee pulp extract. Three factors (precursor concentration, reducing agent concentration, and reaction time) were considered and their combined effects on the maximum intensity MA, particle size d, and particle density N were analyzed. An opposing effect between the precursor and reducing agent was observed during synthesis, because although the precursor increased d and diminished N, the reducing agent diminished d and increased N. These effects were observed simultaneously through the response surfaces of d and N. This methodology allowed the synthesis of nanoparticles with an average particle size of 5–22 nm and N around 2.9 x 1011 3.7 x 1013 part/mL, depending on the response surface methodology, Box–Behnken design. The R2 value determined for all cases was 0.98 (MA), 0.99 (d), and 0.97 (N), clearly indicating that the model can be used to predict or design the response variables in the design space. Finally, Fourier transform infrared measurements showed that the organic compounds present in the aqueous coffee pulp extract were coating the surface of the gold nanoparticles. The proposed methodology could contribute to the design of new alternatives for the synthesis of specific nanostructures with potential applications in the therapeutic area.
KW - Aqueous coffee pulp extract
KW - Box–Behnken design
KW - Gold nanoparticles
KW - Green synthesis
KW - Response surface methodology
UR - http://www.scopus.com/inward/record.url?scp=85106925210&partnerID=8YFLogxK
U2 - 10.1139/cjc-2020-0360
DO - 10.1139/cjc-2020-0360
M3 - Artículo
AN - SCOPUS:85106925210
SN - 0008-4042
VL - 99
SP - 519
EP - 530
JO - Canadian Journal of Chemistry
JF - Canadian Journal of Chemistry
IS - 6
ER -