Analgesic effects of B vitamins: A review

Research output: Contribution to journalScientific review

3 Citations (Scopus)

Abstract

B vitamins have been used as analgesic drugs to treat pain disorders associated with their deficiency. However, more recently it has been claimed that, at pharmacological doses, B vitamins are useful to relieve different pain states as carpal tunnel, migraine and premenstrual tension. Experiments in animals have shown that vitamins B1 (thiamine), B6 (pyridoxine) and B12 (cyanocobalamin) and their combination have antinociceptive activity against chemical- and heat-induced pain. An anti-inflammatory effect has also been reported using the carrageenin-induced edema test. Moreover, the individual administration of thiamine and pyridoxine produce antinociception in acetic acid-induced pain or pain induced by supramaximal electrical stimulation of afferent C fibers. However, the most important effect of B vitamins is related with its use in patients with neuropathic pain. B vitamins have been useful in some painful disorders such as polyneuropathy, neuralgia, radiculopathy, neuritis associated with pain paresthesias, and diabetic peripheral neuropathy. This use has been supported recently by preclinical studies showing the efficacy of these vitamins in well established models of neuropathic pain in rats. The neurophysiological mechanisms induced by B vitamins are still unknown. However, in the last years it has been postulated that B vitamins-induced antinociception could result from activation of opioid receptors or nitric oxide release.
Original languageAmerican English
Pages (from-to)1-31
Number of pages3
JournalCurrent Topics in Pharmacology
StatePublished - 1 Dec 2006

Fingerprint

Vitamin B Complex
Vitamin A
Analgesics
Thiamine
Neuralgia
Pain
Pyridoxine
Premenstrual Syndrome
Neuritis
Unmyelinated Nerve Fibers
Somatoform Disorders
Radiculopathy
Polyneuropathies
Diabetic Neuropathies
Paresthesia
Carrageenan
Opioid Receptors
Peripheral Nervous System Diseases
Vitamin B 12
Wrist

Cite this

@article{88fb103c851f420fa0b3a13ffd974eb8,
title = "Analgesic effects of B vitamins: A review",
abstract = "B vitamins have been used as analgesic drugs to treat pain disorders associated with their deficiency. However, more recently it has been claimed that, at pharmacological doses, B vitamins are useful to relieve different pain states as carpal tunnel, migraine and premenstrual tension. Experiments in animals have shown that vitamins B1 (thiamine), B6 (pyridoxine) and B12 (cyanocobalamin) and their combination have antinociceptive activity against chemical- and heat-induced pain. An anti-inflammatory effect has also been reported using the carrageenin-induced edema test. Moreover, the individual administration of thiamine and pyridoxine produce antinociception in acetic acid-induced pain or pain induced by supramaximal electrical stimulation of afferent C fibers. However, the most important effect of B vitamins is related with its use in patients with neuropathic pain. B vitamins have been useful in some painful disorders such as polyneuropathy, neuralgia, radiculopathy, neuritis associated with pain paresthesias, and diabetic peripheral neuropathy. This use has been supported recently by preclinical studies showing the efficacy of these vitamins in well established models of neuropathic pain in rats. The neurophysiological mechanisms induced by B vitamins are still unknown. However, in the last years it has been postulated that B vitamins-induced antinociception could result from activation of opioid receptors or nitric oxide release.",
author = "Gerardo Reyes-Garc{\'i}a and Roberto Medina-Santill{\'a}n and Flores-Murrieta, {Francisco J.} and Caram-Salas, {Nadia L.} and Vinicio Granados-Soto",
year = "2006",
month = "12",
day = "1",
language = "American English",
pages = "1--31",
journal = "Current Topics in Pharmacology",
issn = "0972-4559",
publisher = "Research Trends",

}

Analgesic effects of B vitamins: A review. / Reyes-García, Gerardo; Medina-Santillán, Roberto; Flores-Murrieta, Francisco J.; Caram-Salas, Nadia L.; Granados-Soto, Vinicio.

In: Current Topics in Pharmacology, 01.12.2006, p. 1-31.

Research output: Contribution to journalScientific review

TY - JOUR

T1 - Analgesic effects of B vitamins: A review

AU - Reyes-García, Gerardo

AU - Medina-Santillán, Roberto

AU - Flores-Murrieta, Francisco J.

AU - Caram-Salas, Nadia L.

AU - Granados-Soto, Vinicio

PY - 2006/12/1

Y1 - 2006/12/1

N2 - B vitamins have been used as analgesic drugs to treat pain disorders associated with their deficiency. However, more recently it has been claimed that, at pharmacological doses, B vitamins are useful to relieve different pain states as carpal tunnel, migraine and premenstrual tension. Experiments in animals have shown that vitamins B1 (thiamine), B6 (pyridoxine) and B12 (cyanocobalamin) and their combination have antinociceptive activity against chemical- and heat-induced pain. An anti-inflammatory effect has also been reported using the carrageenin-induced edema test. Moreover, the individual administration of thiamine and pyridoxine produce antinociception in acetic acid-induced pain or pain induced by supramaximal electrical stimulation of afferent C fibers. However, the most important effect of B vitamins is related with its use in patients with neuropathic pain. B vitamins have been useful in some painful disorders such as polyneuropathy, neuralgia, radiculopathy, neuritis associated with pain paresthesias, and diabetic peripheral neuropathy. This use has been supported recently by preclinical studies showing the efficacy of these vitamins in well established models of neuropathic pain in rats. The neurophysiological mechanisms induced by B vitamins are still unknown. However, in the last years it has been postulated that B vitamins-induced antinociception could result from activation of opioid receptors or nitric oxide release.

AB - B vitamins have been used as analgesic drugs to treat pain disorders associated with their deficiency. However, more recently it has been claimed that, at pharmacological doses, B vitamins are useful to relieve different pain states as carpal tunnel, migraine and premenstrual tension. Experiments in animals have shown that vitamins B1 (thiamine), B6 (pyridoxine) and B12 (cyanocobalamin) and their combination have antinociceptive activity against chemical- and heat-induced pain. An anti-inflammatory effect has also been reported using the carrageenin-induced edema test. Moreover, the individual administration of thiamine and pyridoxine produce antinociception in acetic acid-induced pain or pain induced by supramaximal electrical stimulation of afferent C fibers. However, the most important effect of B vitamins is related with its use in patients with neuropathic pain. B vitamins have been useful in some painful disorders such as polyneuropathy, neuralgia, radiculopathy, neuritis associated with pain paresthesias, and diabetic peripheral neuropathy. This use has been supported recently by preclinical studies showing the efficacy of these vitamins in well established models of neuropathic pain in rats. The neurophysiological mechanisms induced by B vitamins are still unknown. However, in the last years it has been postulated that B vitamins-induced antinociception could result from activation of opioid receptors or nitric oxide release.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=36749078594&origin=inward

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=36749078594&origin=inward

M3 - Scientific review

SP - 1

EP - 31

JO - Current Topics in Pharmacology

JF - Current Topics in Pharmacology

SN - 0972-4559

ER -