An overview of the infection of CMV, HSV 1/2 and EBV in Mexican patients with glioblastoma multiforme

Sergio Zavala-Vega, Graciela Castro-Escarpulli, Hector Hernández-Santos, Citlatepetl Salinas-Lara, Icela Palma, Juan Manuel Mejía-Aranguré, Noemí Gelista-Herrera, Daniel Rembao-Bojorquez, Sara A. Ochoa, Ariadnna Cruz-Córdova, Juan Xicohtencatl-Cortes, Gabriel Uribe-Gutiérrez, José Arellano-Galindo

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Several risk factors are involved in glioblastoma, including cytomegalovirus (CMV). This research was carried out to determine the rate of CMV infection, as well as HSV 1/2 and EBV in brain tissue, in patients with glioblastomamultiforme (GBM). The tissues were tested using immunohistochemistry, PCR, in situ hybridization and real-time PCR. At least, one HHV was detected in 21/29 (72%) patients as follows: single infections with HSV-1/2 in 4/21 (19%), EBV in 6/21 (28.6%) and CMV in 1/21 (4.8%). Mixed viral infection, HSV-1/2 and EBV were detected in 4/21 patients (19%), CMV and EBV in 5/21 (23.8%), and HSV-1/2, EBV, and CMV in 1/21. The CMV viral load ranged from 3 × 102 to 4.33 × 105 genome/100 ng of tissue. Genotype based on CMV gB was 3/7 where 2/3 was gB1 and 1/3 gB4. HSV, EBV and CMV were frequently found in brain tissues, more in mix in a population reported as highly seropositive.

Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalPathology Research and Practice
Volume213
Issue number3
DOIs
StatePublished - 1 Mar 2017

Keywords

  • Cytomegalovirus
  • Epstein–Barr
  • Glioblastomamultiforme
  • HHVs
  • Herpes
  • Viral infection

Fingerprint

Dive into the research topics of 'An overview of the infection of CMV, HSV 1/2 and EBV in Mexican patients with glioblastoma multiforme'. Together they form a unique fingerprint.

Cite this