Abstract
A copper-free intramolecular azide-alkyne cycloaddition reaction of 4-hydroxymethyl-β-lactam with sodium azide has been described. The present approach involves the incorporation of an alkyne moiety through O-alkynylation of 3-hydroxy β-lactam with various propargylic halides. The generality of the method has been demonstrated by treating the corresponding tosylates or mesylates of the hydroxymethyl functionality of a variety of β-lactam-tethered terminal and internal alkynes with sodium azide in a one-pot three-step reaction to furnish novel oxazepane-β-lactam fused triazole scaffolds of diverse interest in good yield.
Original language | English |
---|---|
Pages (from-to) | 654-657 |
Number of pages | 4 |
Journal | Australian Journal of Chemistry |
Volume | 73 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2020 |
Externally published | Yes |