TY - JOUR
T1 - Aluminum-induced oxidative stress and apoptosis in liver of the common carp, cyprinus carpio
AU - Razo-Estrada, A. C.
AU - García-Medina, S.
AU - Madrigal-Bujaidar, E.
AU - Gómez-Oliván, L. M.
AU - Galar-Martínez, M.
N1 - Funding Information:
Acknowledgments This study was made possible through support from the National Science and Technology Council (CONACyT, projects 57321 and 181541) as well as the Research and Postgraduate Division of the National Polytechnic Institute, Mexico (SIP-IPN, projects 20060186 and 200704594).
PY - 2013/5
Y1 - 2013/5
N2 - Although aluminum (Al) is considered innocuous to living beings, exposure to high concentrations can elicit damage. Al has been found to cause liver pathologies in various animal models. Its mechanisms of toxicity are unclear; presumably, it interacts with protein sulfhydryl groups and promotes reactive oxygen species formation causing oxidative stress. Lipid peroxidation, protein carbonyl content, and activity of superoxide dismutase, catalase, and caspase-3 were determined in liver of Cyprinus carpio exposed to 0.05, 120, and 239.42 mg Al L-1 for 12, 24, 48, 72, and 96 h. Al induced increased lipid peroxidation and protein carbonyl content as well as changes in enzymatic activity, indicating it elicits oxidative stress and apoptosis in common carp liver.
AB - Although aluminum (Al) is considered innocuous to living beings, exposure to high concentrations can elicit damage. Al has been found to cause liver pathologies in various animal models. Its mechanisms of toxicity are unclear; presumably, it interacts with protein sulfhydryl groups and promotes reactive oxygen species formation causing oxidative stress. Lipid peroxidation, protein carbonyl content, and activity of superoxide dismutase, catalase, and caspase-3 were determined in liver of Cyprinus carpio exposed to 0.05, 120, and 239.42 mg Al L-1 for 12, 24, 48, 72, and 96 h. Al induced increased lipid peroxidation and protein carbonyl content as well as changes in enzymatic activity, indicating it elicits oxidative stress and apoptosis in common carp liver.
KW - Aluminum
KW - Apoptosis
KW - Cyprinus carpio
KW - Liver
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=84875536642&partnerID=8YFLogxK
U2 - 10.1007/s11270-013-1510-8
DO - 10.1007/s11270-013-1510-8
M3 - Artículo
SN - 0049-6979
VL - 224
JO - Water, Air, and Soil Pollution
JF - Water, Air, and Soil Pollution
IS - 5
M1 - 1510
ER -