TY - JOUR
T1 - Alginate hydrogels for bone tissue engineering, from injectables to bioprinting
T2 - A review
AU - Hernández-González, Aurora C.
AU - Téllez-Jurado, Lucía
AU - Rodríguez-Lorenzo, Luis M.
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/2/1
Y1 - 2020/2/1
N2 - This review focuses on recently developed alginate injectable hydrogels and alginate composites for applications in bone tissue regeneration, and it evaluates the alternatives to overcome the problems that avoid their utilization in the field. Section 2 covers the properties of alginates that have made them useful for medical applications, in particular their ionic gelling ability for preparing injectable compositions used as delivery drugs systems. The advantages and shortcomings of these preparations are revised together with the chemical modifications assayed. Section 3 describes how it has been taken advantage of alginates into the new field of biofabrication and the developments in bone engineering. The state of the art of this field is reviewed. Finally in Section 4, new developments and approaches that in opinion of the authors can lead to a breakthrough in bone tissue engineering using alginates are introduced.
AB - This review focuses on recently developed alginate injectable hydrogels and alginate composites for applications in bone tissue regeneration, and it evaluates the alternatives to overcome the problems that avoid their utilization in the field. Section 2 covers the properties of alginates that have made them useful for medical applications, in particular their ionic gelling ability for preparing injectable compositions used as delivery drugs systems. The advantages and shortcomings of these preparations are revised together with the chemical modifications assayed. Section 3 describes how it has been taken advantage of alginates into the new field of biofabrication and the developments in bone engineering. The state of the art of this field is reviewed. Finally in Section 4, new developments and approaches that in opinion of the authors can lead to a breakthrough in bone tissue engineering using alginates are introduced.
KW - Alginate hydrogel
KW - Bioprinting
KW - Bone tissue
KW - Composite
KW - Hybrid
KW - Injectable
UR - http://www.scopus.com/inward/record.url?scp=85075393522&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2019.115514
DO - 10.1016/j.carbpol.2019.115514
M3 - Artículo de revisión
C2 - 31826429
AN - SCOPUS:85075393522
SN - 0144-8617
VL - 229
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
M1 - 115514
ER -