TY - JOUR
T1 - Acute toxicity and mutagenic activity of Mexican plants used in traditional medicine
AU - Déciga-Campos, Myrna
AU - Rivero-Cruz, Isabel
AU - Arriaga-Alba, Myriam
AU - Castañeda-Corral, Gabriela
AU - Angeles-López, Guadalupe E.
AU - Navarrete, Andrés
AU - Mata, Rachel
N1 - Funding Information:
This research was supported by a CONACyT grant (C01-018) and DGAPA (IN212005). Myrna Déciga-Campos is a DGAPA postdoctoral fellow.
PY - 2007/3/21
Y1 - 2007/3/21
N2 - The present work was undertaken to determine safety parameters of selected Mexican medicinal plants chosen on the basis of their frequency of medicinal use and commercial importance. The medicinal herbs included Amphipteryngium adstringens, Hintonia standleyana, Hintonia latiflora, Piper sanctum, Haemathoxylon brasiletto, Iostephane heterophylla, Valeriana procera, Arracacia tolucensis, Brickellia veronicaefolia, Scaphyglottis livida, Exostema caribaeum, Hippocratea excelsa, Ligusticum porteri, Poliomintha longiflora and Gnaphalium sp. In the acute toxicity studies in mice performed according to the Lorke procedure, Exostema caribaeum, Hippocratea excelsa, Ligusticum porteri and Poliomintha longiflora were the most toxic with LD50 values between 1085 and 2 mg/kg. The Ames test revealed that Gnaphalium sp. and Valeriana procera extracts induced mutations of S. typhimurium TA98 with or without the S9 microsomal fraction, and TA100 in the presence of the enzymatic fraction, respectively. The tincture of Valeriana procera, however, was non-mutagenic. Finally, in the Artemia salina lethality test Brickellia veronicaefolia, Arracacia tolucensis, Poliomintha longiflora and Piper sanctum caused significant mortality of the crustacean larvae with LC50 in the range of 37-227 μg/mL.
AB - The present work was undertaken to determine safety parameters of selected Mexican medicinal plants chosen on the basis of their frequency of medicinal use and commercial importance. The medicinal herbs included Amphipteryngium adstringens, Hintonia standleyana, Hintonia latiflora, Piper sanctum, Haemathoxylon brasiletto, Iostephane heterophylla, Valeriana procera, Arracacia tolucensis, Brickellia veronicaefolia, Scaphyglottis livida, Exostema caribaeum, Hippocratea excelsa, Ligusticum porteri, Poliomintha longiflora and Gnaphalium sp. In the acute toxicity studies in mice performed according to the Lorke procedure, Exostema caribaeum, Hippocratea excelsa, Ligusticum porteri and Poliomintha longiflora were the most toxic with LD50 values between 1085 and 2 mg/kg. The Ames test revealed that Gnaphalium sp. and Valeriana procera extracts induced mutations of S. typhimurium TA98 with or without the S9 microsomal fraction, and TA100 in the presence of the enzymatic fraction, respectively. The tincture of Valeriana procera, however, was non-mutagenic. Finally, in the Artemia salina lethality test Brickellia veronicaefolia, Arracacia tolucensis, Poliomintha longiflora and Piper sanctum caused significant mortality of the crustacean larvae with LC50 in the range of 37-227 μg/mL.
KW - Acute toxicity
KW - Ames test
KW - Brine shrimp test
KW - Lorke method
KW - Mexican medicinal plants
KW - Mexican traditional medicine
UR - http://www.scopus.com/inward/record.url?scp=33847235687&partnerID=8YFLogxK
U2 - 10.1016/j.jep.2006.10.001
DO - 10.1016/j.jep.2006.10.001
M3 - Artículo
C2 - 17101253
SN - 0378-8741
VL - 110
SP - 334
EP - 342
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 2
ER -