Cytotoxic activity of ethanolic extracts of Lippia graveolens HBK leaves and stem against lung cancer cell line SK-LU-1

María Estela Frías-Zepeda; Jorge Ibarra-Berumen; Cynthia Ordaz-Pichardo; Martha Rosales-Castro

doi:10.37360/blacpma.22.21.5.40

Cytotoxic activity of ethanolic extracts of Lippia graveolens HBK leaves and stem against lung cancer cell line SK-LU-1

Translated title of the contribution: Cytotoxic activity of ethanolic extracts of Lippia graveolens HBK leaves and stem against lung cancer cell line SK-LU-1

María Estela Frías-Zepeda, Jorge Ibarra-Berumen, Cynthia Ordaz-Pichardo, Martha Rosales-Castro

Research output: Contribution to journal › Article › peer-review

Abstract

Lippia graveolens HBK (Verbenaceae) is an aromatic herb of economic importance in Mexico, known as oregano. The leaves are used as condiments, and people use this species for respiratory and digestive disorders. The aim of this work was to evaluate the cytotoxic effect of ethanolic extracts obtained from free-oil leaves (L9) and stem (S15), against lung cancer cell line SK-LU-1, through tetrazolium salt (MTT) assay. Extracts concentrations of 0.3 to 300 µg/mL were used and HFF-1 as normal control cells. Both L9 and S15 extracts, showed cytotoxic effect, although stem was stronger than leaves and without damage to normal cell control. The phenolic compounds caffeic acid and acacetin were in higher concentration in L9, whereas naringenin, taxifolin, eriodictyol, luteolin, and apigenin had higher concentrations in S15. The ethanolic extracts of L. graveolens have excellent cytotoxic activity, and have a wide possibility of use in lung cancer treatment.

Translated title of the contribution	Cytotoxic activity of ethanolic extracts of Lippia graveolens HBK leaves and stem against lung cancer cell line SK-LU-1
Original language	English
Pages (from-to)	646-653
Number of pages	8
Journal	Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
Volume	21
Issue number	5
DOIs	https://doi.org/10.37360/blacpma.22.21.5.40
State	Published - Sep 2022

Keywords

Cytotoxic activity
Ethanolic extract
Lippia graveolens HBK
Lung cancer
SK-LU-1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.37360/blacpma.22.21.5.40

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title = "Cytotoxic activity of ethanolic extracts of Lippia graveolens HBK leaves and stem against lung cancer cell line SK-LU-1",

abstract = "Lippia graveolens HBK (Verbenaceae) is an aromatic herb of economic importance in Mexico, known as oregano. The leaves are used as condiments, and people use this species for respiratory and digestive disorders. The aim of this work was to evaluate the cytotoxic effect of ethanolic extracts obtained from free-oil leaves (L9) and stem (S15), against lung cancer cell line SK-LU-1, through tetrazolium salt (MTT) assay. Extracts concentrations of 0.3 to 300 µg/mL were used and HFF-1 as normal control cells. Both L9 and S15 extracts, showed cytotoxic effect, although stem was stronger than leaves and without damage to normal cell control. The phenolic compounds caffeic acid and acacetin were in higher concentration in L9, whereas naringenin, taxifolin, eriodictyol, luteolin, and apigenin had higher concentrations in S15. The ethanolic extracts of L. graveolens have excellent cytotoxic activity, and have a wide possibility of use in lung cancer treatment.",

keywords = "Cytotoxic activity, Ethanolic extract, Lippia graveolens HBK, Lung cancer, SK-LU-1",

author = "Fr{\'i}as-Zepeda, {Mar{\'i}a Estela} and Jorge Ibarra-Berumen and Cynthia Ordaz-Pichardo and Martha Rosales-Castro",

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Cytotoxic activity of ethanolic extracts of Lippia graveolens HBK leaves and stem against lung cancer cell line SK-LU-1. / Frías-Zepeda, María Estela; Ibarra-Berumen, Jorge; Ordaz-Pichardo, Cynthia et al.
In: Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, Vol. 21, No. 5, 09.2022, p. 646-653.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Cytotoxic activity of ethanolic extracts of Lippia graveolens HBK leaves and stem against lung cancer cell line SK-LU-1

AU - Frías-Zepeda, María Estela

AU - Ibarra-Berumen, Jorge

AU - Ordaz-Pichardo, Cynthia

AU - Rosales-Castro, Martha

PY - 2022/9

Y1 - 2022/9

N2 - Lippia graveolens HBK (Verbenaceae) is an aromatic herb of economic importance in Mexico, known as oregano. The leaves are used as condiments, and people use this species for respiratory and digestive disorders. The aim of this work was to evaluate the cytotoxic effect of ethanolic extracts obtained from free-oil leaves (L9) and stem (S15), against lung cancer cell line SK-LU-1, through tetrazolium salt (MTT) assay. Extracts concentrations of 0.3 to 300 µg/mL were used and HFF-1 as normal control cells. Both L9 and S15 extracts, showed cytotoxic effect, although stem was stronger than leaves and without damage to normal cell control. The phenolic compounds caffeic acid and acacetin were in higher concentration in L9, whereas naringenin, taxifolin, eriodictyol, luteolin, and apigenin had higher concentrations in S15. The ethanolic extracts of L. graveolens have excellent cytotoxic activity, and have a wide possibility of use in lung cancer treatment.

AB - Lippia graveolens HBK (Verbenaceae) is an aromatic herb of economic importance in Mexico, known as oregano. The leaves are used as condiments, and people use this species for respiratory and digestive disorders. The aim of this work was to evaluate the cytotoxic effect of ethanolic extracts obtained from free-oil leaves (L9) and stem (S15), against lung cancer cell line SK-LU-1, through tetrazolium salt (MTT) assay. Extracts concentrations of 0.3 to 300 µg/mL were used and HFF-1 as normal control cells. Both L9 and S15 extracts, showed cytotoxic effect, although stem was stronger than leaves and without damage to normal cell control. The phenolic compounds caffeic acid and acacetin were in higher concentration in L9, whereas naringenin, taxifolin, eriodictyol, luteolin, and apigenin had higher concentrations in S15. The ethanolic extracts of L. graveolens have excellent cytotoxic activity, and have a wide possibility of use in lung cancer treatment.

KW - Cytotoxic activity

KW - Ethanolic extract

KW - Lippia graveolens HBK

KW - Lung cancer

KW - SK-LU-1

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DO - 10.37360/blacpma.22.21.5.40

M3 - Artículo

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VL - 21

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JO - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas

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ER -

Cytotoxic activity of ethanolic extracts of Lippia graveolens HBK leaves and stem against lung cancer cell line SK-LU-1

Abstract

Keywords

UN SDGs

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