TY - JOUR
T1 - Abscopal Effect, Extracellular Vesicles and Their Immunotherapeutic Potential in Cancer Treatment
AU - Salazar, Aleli
AU - Chavarria, Víctor
AU - Flores, Itamar
AU - Ruiz, Samanta
AU - Pérez de la Cruz, Verónica
AU - Sánchez-García, Francisco Javier
AU - Pineda, Benjamin
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/5
Y1 - 2023/5
N2 - The communication between tumor cells and the microenvironment plays a fundamental role in the development, growth and further immune escape of the tumor. This communication is partially regulated by extracellular vesicles which can direct the behavior of surrounding cells. In recent years, it has been proposed that this feature could be applied as a potential treatment against cancer, since several studies have shown that tumors treated with radiotherapy can elicit a strong enough immune response to eliminate distant metastasis; this phenomenon is called the abscopal effect. The mechanism behind this effect may include the release of extracellular vesicles loaded with damage-associated molecular patterns and tumor-derived antigens which activates an antigen-specific immune response. This review will focus on the recent discoveries in cancer cell communications via extracellular vesicles and their implication in tumor development, as well as their potential use as an immunotherapeutic treatment against cancer.
AB - The communication between tumor cells and the microenvironment plays a fundamental role in the development, growth and further immune escape of the tumor. This communication is partially regulated by extracellular vesicles which can direct the behavior of surrounding cells. In recent years, it has been proposed that this feature could be applied as a potential treatment against cancer, since several studies have shown that tumors treated with radiotherapy can elicit a strong enough immune response to eliminate distant metastasis; this phenomenon is called the abscopal effect. The mechanism behind this effect may include the release of extracellular vesicles loaded with damage-associated molecular patterns and tumor-derived antigens which activates an antigen-specific immune response. This review will focus on the recent discoveries in cancer cell communications via extracellular vesicles and their implication in tumor development, as well as their potential use as an immunotherapeutic treatment against cancer.
KW - DAMPs
KW - abscopal effect
KW - cancer
KW - extracellular vesicles
UR - http://www.scopus.com/inward/record.url?scp=85159259139&partnerID=8YFLogxK
U2 - 10.3390/molecules28093816
DO - 10.3390/molecules28093816
M3 - Artículo de revisión
C2 - 37175226
AN - SCOPUS:85159259139
SN - 1420-3049
VL - 28
JO - Molecules
JF - Molecules
IS - 9
M1 - 3816
ER -