Abstract
Background: Carbonyl groups are important functional groups and they play a key role in organic chemistry. This group needs to be protected in multistep synthesis against various reagents for a counter-reaction. The effort towards developing an efficient methodology for the protection of carbonyl functional group is always a demanding reaction. The protection of carbonyl compounds for inhibiting their chemical reactivity is an important operation in chemistry. In this paper, camphor sulfonic acid-catalysed protection of various carbonyl compounds is developed. This method is simple, environmentally friendly and yields products in high yields. Method: Commercially available camphor sulfonic acid is used as organo-catalyst for the protection of carbonyl functionality. This catalyst is also employed for the protection of carbonyl functionality as thioacetal/mixed ketal in excellent yield. The newly synthesize compounds are characterized using 1HNMR, 13C NMR and IR spectroscopy. Result: A diverse carbonyl functional group is protected in excellent yield under mild reaction conditions. Conclusion: We have developed an efficient organocatalysed protection method of carbonyl functionality applicable to wide range of substrates.
| Original language | English |
|---|---|
| Pages (from-to) | 196-200 |
| Number of pages | 5 |
| Journal | Current Organocatalysis |
| Volume | 5 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2018 |
| Externally published | Yes |
Keywords
- 1,3-dioxolane
- Acetal
- Camphor sulfonic acid
- Ketal
- Organocatalysis
- Protection
- Thioketalization