TY - JOUR
T1 - A semi-targeted NMR-based chemical profiling of retail samples of Mexican gordolobo
AU - Ontiveros-Rodríguez, Julio C.
AU - Serrano-Contreras, José I.
AU - Villagómez-Ibarra, José Roberto
AU - García-Gutiérrez, Hugo A.
AU - Gerardo Zepeda-Vallejo, L.
N1 - Publisher Copyright:
© 2022
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Mexican gordolobo (MG) is one of the most important medicinal plants in Mexico and an important source of specialized metabolites with biological activities. The species employed in Mexican traditional medicine identified with this name are very different and difficult to identify according to existent criteria. In order to contribute to the identification of these species, a semi-targeted 1H NMR-based chemometric method was developed to characterize the chemical profiling of retail samples of MG. Thus, 17 retail samples of MG flowers were successively extracted with a gradient of water:chloroform (1:4, 1:2 and 0:1) in an ultrasonic bath for 15 min each. The organic phase of the three extracts was pooled, evaporated and analyzed by 1H NMR. The NMR data were subjected to multivariate statistical analysis, revealing that flavones gnaphaliin A (1), gnaphaliin B (2), araneol (3), 3,5,7-Tri-O-methylgalangin (4) and diterpenes sclareol (5) and kaur-16-en-18-oic acid (6) can be effectively used as chemotaxonomical markers for the correct identification of the Gnaphalium spp that compose MG. The aforementioned chemotaxonomic markers may be useful in establishing therapeutic criteria.
AB - Mexican gordolobo (MG) is one of the most important medicinal plants in Mexico and an important source of specialized metabolites with biological activities. The species employed in Mexican traditional medicine identified with this name are very different and difficult to identify according to existent criteria. In order to contribute to the identification of these species, a semi-targeted 1H NMR-based chemometric method was developed to characterize the chemical profiling of retail samples of MG. Thus, 17 retail samples of MG flowers were successively extracted with a gradient of water:chloroform (1:4, 1:2 and 0:1) in an ultrasonic bath for 15 min each. The organic phase of the three extracts was pooled, evaporated and analyzed by 1H NMR. The NMR data were subjected to multivariate statistical analysis, revealing that flavones gnaphaliin A (1), gnaphaliin B (2), araneol (3), 3,5,7-Tri-O-methylgalangin (4) and diterpenes sclareol (5) and kaur-16-en-18-oic acid (6) can be effectively used as chemotaxonomical markers for the correct identification of the Gnaphalium spp that compose MG. The aforementioned chemotaxonomic markers may be useful in establishing therapeutic criteria.
KW - Chemical profiling
KW - Gnaphalium
KW - Mexican gordolobo
UR - http://www.scopus.com/inward/record.url?scp=85124298600&partnerID=8YFLogxK
U2 - 10.1016/j.jpba.2022.114651
DO - 10.1016/j.jpba.2022.114651
M3 - Artículo
C2 - 35152008
AN - SCOPUS:85124298600
SN - 0731-7085
VL - 212
JO - Journal of Pharmaceutical and Biomedical Analysis
JF - Journal of Pharmaceutical and Biomedical Analysis
M1 - 114651
ER -