TY - GEN
T1 - A pilot assay of interstitial photodynamic therapy with high-power laser system BioSpec® in a syngeneic breast cancer model
AU - Araujo-Padilla, Xelha
AU - Delgado-López, María Guadalupe
AU - Beltrán-Ortega, Carlos
AU - Ramón-Gallegos, Eva
N1 - Publisher Copyright:
© 2019 Author(s).
PY - 2019/4/10
Y1 - 2019/4/10
N2 - Photodynamic therapy (PDT) is a new technique that has already been applied to several types of cancer, which combines a photosensitizer, light and oxygen. Interstitial PDT is based on intra-tumor light delivery using laser fibers inserted via needle. In this work, the fiber TF-N09 and the high-power laser system BIOSPEC® were tested in a syngeneic breast cancer mouse model. Results obtained in this work indicates that the irradiation causes necrosis in both groups, a group treated with pre-photosensitizer and a non-treated group. Also, the maximum potency usable with this device was 500mW, since at a higher power the needle reached temperatures above 37 °C.
AB - Photodynamic therapy (PDT) is a new technique that has already been applied to several types of cancer, which combines a photosensitizer, light and oxygen. Interstitial PDT is based on intra-tumor light delivery using laser fibers inserted via needle. In this work, the fiber TF-N09 and the high-power laser system BIOSPEC® were tested in a syngeneic breast cancer mouse model. Results obtained in this work indicates that the irradiation causes necrosis in both groups, a group treated with pre-photosensitizer and a non-treated group. Also, the maximum potency usable with this device was 500mW, since at a higher power the needle reached temperatures above 37 °C.
UR - http://www.scopus.com/inward/record.url?scp=85064875935&partnerID=8YFLogxK
U2 - 10.1063/1.5095904
DO - 10.1063/1.5095904
M3 - Contribución a la conferencia
AN - SCOPUS:85064875935
T3 - AIP Conference Proceedings
BT - XV Mexican Symposium on Medical Physics
A2 - Trevino-Palacios, Carlos-Gerardo
A2 - Garcia-Pelagio, Karla-Paola
A2 - Avila-Aguirre, Olga-Leticia
A2 - Fossion, Ruben
A2 - Brandan, Maria-Ester
A2 - Hernandez-Bojorquez, Mariana
PB - American Institute of Physics Inc.
T2 - 15th Mexican Symposium on Medical Physics
Y2 - 13 June 2018 through 15 June 2018
ER -
