A new homologous series of anticonvulsants: Phenyl alcohol amides. Synthesis and pharmacological evaluation

S. E. Mezo-Toledo, M. T. Zenteno-Garcia, E. Juarez-Carvajal, D. Martinez-Munoz, G. Carvajal-Sandoval

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Abstract

The anticonvulsant activity of a homologous series of phenyl alcohol amides is described. (±)-2-Hydroxy-2-phenylbutyramide (1), (±)-3-hydroxy-3-phenylpentanamide (2) and (±)-4-hydroxy-4-phenylhexanamide (3) were prepared and tested for their anticonvulsant profile and neurotoxicity. 1, 2 and 3 exhibited a broad profile of anticonvulsant activity and a similar significant activity in the seizures provoked by maximal electroshock, pentetrazol, 4-aminopyridine, bicuculline and thiosemicarbazide, but in the strychnine and picrotoxin tests, the protection was variable. The rotarod ataxia test was used to evaluate their neurotoxicity. In this test 2 possesses the lowest neurotoxicity.
Original languageAmerican English
Pages (from-to)1289-1291
Number of pages1159
JournalArzneimittel-Forschung/Drug Research
StatePublished - 1 Dec 1990

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anticonvulsants
Amides
Anticonvulsants
amides
alcohols
Alcohols
gamma-hydroxy-gamma-ethyl-gamma-phenylbutyramide
Pharmacology
evaluation
strychnine
synthesis
Rotarod Performance Test
ataxia
seizures
Strychnine
Picrotoxin
Electroshock
4-Aminopyridine
Bicuculline
Ataxia

Cite this

Mezo-Toledo, S. E., Zenteno-Garcia, M. T., Juarez-Carvajal, E., Martinez-Munoz, D., & Carvajal-Sandoval, G. (1990). A new homologous series of anticonvulsants: Phenyl alcohol amides. Synthesis and pharmacological evaluation. Arzneimittel-Forschung/Drug Research, 1289-1291.
Mezo-Toledo, S. E. ; Zenteno-Garcia, M. T. ; Juarez-Carvajal, E. ; Martinez-Munoz, D. ; Carvajal-Sandoval, G. / A new homologous series of anticonvulsants: Phenyl alcohol amides. Synthesis and pharmacological evaluation. In: Arzneimittel-Forschung/Drug Research. 1990 ; pp. 1289-1291.
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Mezo-Toledo, SE, Zenteno-Garcia, MT, Juarez-Carvajal, E, Martinez-Munoz, D & Carvajal-Sandoval, G 1990, 'A new homologous series of anticonvulsants: Phenyl alcohol amides. Synthesis and pharmacological evaluation', Arzneimittel-Forschung/Drug Research, pp. 1289-1291.

A new homologous series of anticonvulsants: Phenyl alcohol amides. Synthesis and pharmacological evaluation. / Mezo-Toledo, S. E.; Zenteno-Garcia, M. T.; Juarez-Carvajal, E.; Martinez-Munoz, D.; Carvajal-Sandoval, G.

In: Arzneimittel-Forschung/Drug Research, 01.12.1990, p. 1289-1291.

Research output: Contribution to journalArticleResearchpeer-review

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