TY - JOUR
T1 - A new homologous series of anticonvulsants
T2 - Phenyl alcohol amides. Synthesis and pharmacological evaluation
AU - Mezo-Toledo, S. E.
AU - Zenteno-Garcia, M. T.
AU - Juarez-Carvajal, E.
AU - Martinez-Munoz, D.
AU - Carvajal-Sandoval, G.
PY - 1990
Y1 - 1990
N2 - The anticonvulsant activity of a homologous series of phenyl alcohol amides is described. (±)-2-Hydroxy-2-phenylbutyramide (1), (±)-3-hydroxy-3-phenylpentanamide (2) and (±)-4-hydroxy-4-phenylhexanamide (3) were prepared and tested for their anticonvulsant profile and neurotoxicity. 1, 2 and 3 exhibited a broad profile of anticonvulsant activity and a similar significant activity in the seizures provoked by maximal electroshock, pentetrazol, 4-aminopyridine, bicuculline and thiosemicarbazide, but in the strychnine and picrotoxin tests, the protection was variable. The rotarod ataxia test was used to evaluate their neurotoxicity. In this test 2 possesses the lowest neurotoxicity.
AB - The anticonvulsant activity of a homologous series of phenyl alcohol amides is described. (±)-2-Hydroxy-2-phenylbutyramide (1), (±)-3-hydroxy-3-phenylpentanamide (2) and (±)-4-hydroxy-4-phenylhexanamide (3) were prepared and tested for their anticonvulsant profile and neurotoxicity. 1, 2 and 3 exhibited a broad profile of anticonvulsant activity and a similar significant activity in the seizures provoked by maximal electroshock, pentetrazol, 4-aminopyridine, bicuculline and thiosemicarbazide, but in the strychnine and picrotoxin tests, the protection was variable. The rotarod ataxia test was used to evaluate their neurotoxicity. In this test 2 possesses the lowest neurotoxicity.
KW - anticonvulsants
KW - antiepileptics
KW - phenyl alcohol amides, pharmacology, synthesis
UR - http://www.scopus.com/inward/record.url?scp=0025642753&partnerID=8YFLogxK
M3 - Artículo
SN - 0004-4172
VL - 40
SP - 1289
EP - 1291
JO - Arzneimittel-Forschung/Drug Research
JF - Arzneimittel-Forschung/Drug Research
IS - 12
ER -