A glycosaminoglycan-rich fraction from sea cucumber isostichopus badionotus has potent anti-inflammatory properties in vitro and in vivo

Leticia Olivera-Castillo, George Grant, Nuvia Kantún-Moreno, Hirian A. Barrera-Pérez, Jorge Montero, Miguel A. Olvera-Novoa, Leydi M. Carrillo-Cocom, Juan J. Acevedo, Cesar Puerto-Castillo, Victor May Solís, Juan A. Pérez-Vega, Judit Gil-Zamorano, Enrique Hernández-Garibay, María A. Fernández-Herrera, Mayra Pérez-Tapia, Oscar Medina-Contreras, Jairo R. Villanueva-Toledo, Rossanna Rodriguez-Canul, Alberto Dávalos

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Sea cucumber body wall contains several naturally occurring bioactive components that possess health-promoting properties. Isostichopus badionotus from Yucatan, Mexico is heavily fished, but little is known about its bioactive constituents. We previously established that I. badionotus meal had potent anti-inflammatory properties in vivo. We have now screened some of its constituents for anti-inflammatory activity in vitro. Glycosaminoglycan and soluble protein preparations reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammatory responses in HaCaT cells while an ethanol extract had a limited effect. The primary glycosaminoglycan (fucosylated chondroitin sulfate; FCS) was purified and tested for anti-inflammatory activity in vivo. FCS modulated the expression of critical genes, including NF-kB, TNFα, iNOS, and COX-2, and attenuated inflammation and tissue damage caused by TPA in a mouse ear inflammation model. It also mitigated colonic colitis caused in mice by dextran sodium sulfate. FCS from I. badionotus of the Yucatan Peninsula thus had strong anti-inflammatory properties in vivo.

Original languageEnglish
Article number1698
Pages (from-to)1-15
Number of pages15
JournalNutrients
Volume12
Issue number6
DOIs
StatePublished - Jun 2020

Keywords

  • Ear-inflammation
  • Glycosaminoglycans
  • Holothuroids
  • Inflammation

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