TY - JOUR
T1 - A diosgenin-containing water-soluble polymer as model for the controlled release of brassinosteroids
AU - Martínez-García, Ariel
AU - Odio, Oscar F.
AU - Coll, Francisco
AU - Martínez, Ricardo
N1 - Publisher Copyright:
© 2021 Taylor & Francis Group, LLC.
PY - 2022
Y1 - 2022
N2 - Novel water-soluble polymers containing diosgenin moieties have been synthesized in order to study the proper conditions for the design of phytoactive formulations carrying brassinosteroid analogs. Samples are obtained by radical copolymerization between acrylamide (AM) and diosgenin monomaleate (DMM) at different initial feed compositions. The resulting copolymers present variable steroidal molar fractions ranging from 0.01 to 0.12, as calculated by means of 1H NMR spectroscopy. Mao–Huglin method is employed for the estimation of monomer reactivity ratios, which renders 16.884 and 0.0024 for AM and DMM, respectively. Surface tension measurements evidence that copolymers with steroidal content below 0.1 exhibit aqueous stability with micelle formation. Controlled release of diosgenin moieties is achieved through alkaline hydrolysis of the monomaleate ester and followed by conductometry. The process displays second order kinetics with a suitable rate constant value for agricultural applications (0.061 L mol−1 s−1). The proposed formulation can also be extended for other applications of steroidal compounds.
AB - Novel water-soluble polymers containing diosgenin moieties have been synthesized in order to study the proper conditions for the design of phytoactive formulations carrying brassinosteroid analogs. Samples are obtained by radical copolymerization between acrylamide (AM) and diosgenin monomaleate (DMM) at different initial feed compositions. The resulting copolymers present variable steroidal molar fractions ranging from 0.01 to 0.12, as calculated by means of 1H NMR spectroscopy. Mao–Huglin method is employed for the estimation of monomer reactivity ratios, which renders 16.884 and 0.0024 for AM and DMM, respectively. Surface tension measurements evidence that copolymers with steroidal content below 0.1 exhibit aqueous stability with micelle formation. Controlled release of diosgenin moieties is achieved through alkaline hydrolysis of the monomaleate ester and followed by conductometry. The process displays second order kinetics with a suitable rate constant value for agricultural applications (0.061 L mol−1 s−1). The proposed formulation can also be extended for other applications of steroidal compounds.
KW - Brassinosteroid analog
KW - controlled release system
KW - diosgenin
KW - phytoactive polymer
KW - polyacrylamide
UR - http://www.scopus.com/inward/record.url?scp=85099359398&partnerID=8YFLogxK
U2 - 10.1080/00914037.2020.1865350
DO - 10.1080/00914037.2020.1865350
M3 - Artículo
AN - SCOPUS:85099359398
SN - 0091-4037
VL - 71
SP - 579
EP - 588
JO - International Journal of Polymeric Materials and Polymeric Biomaterials
JF - International Journal of Polymeric Materials and Polymeric Biomaterials
IS - 8
ER -