A Convergent Total Synthesis of the Biologically Active Benzofurans Ailanthoidol, Egonol and Homoegonol from Biomass-Derived Eugenol

José C. Espinoza-Hicks, Gerardo Zaragoza-Galán, David Chávez-Flores, Víctor H. Ramos-Sánchez, Joaquín Tamariz, Alejandro A. Camacho-Dávila

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

An efficient, general synthetic protocol for the synthesis of the biologically active benzofurans ailanthoidol, egonol and homoegonol was developed. The key starting material, eugenol, is a naturally occurring and abundant precursor. The protocol, involving sequential acylation and intramolecular Wittig reaction, provides a convenient method for building the benzofuran moiety in good yield.

Original languageEnglish
Article numberss-2018-m0239-op
Pages (from-to)3493-3498
Number of pages6
JournalSynthesis (Germany)
Volume50
Issue number17
DOIs
StatePublished - 2018

Keywords

  • ailanthoidol
  • benzofurans
  • egonol
  • homoegonol
  • natural products
  • sustainable synthesis
  • total synthesis

Fingerprint

Dive into the research topics of 'A Convergent Total Synthesis of the Biologically Active Benzofurans Ailanthoidol, Egonol and Homoegonol from Biomass-Derived Eugenol'. Together they form a unique fingerprint.

Cite this