A Convenient Synthesis of Novel Pyrido(1′,2′: 1,2)imidazo[5,4-d]-1,2,3-triazinones from Imidazo[1,2-a]pyridines

Héctor Salgado Zamora, Benito Rizo, Elena Campos, Rogelio Jiménez, Alicia Reyes

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9 Citations (Scopus)

Abstract

The imidazo [1,2-a]pyridine system was investigated as a synthon for the building of very attractive fused triazines, a planar, angular tri-heterocycle with potential biological activity. Thus ethyl 3-nitroimidazo[1,2-a]pyridine-2-carboxylate was treated with ammonia or with an excess of primary amines to generate the corresponding substituted nitro carboxamidoimidazopyridines. The nitro substituent in the latter products, was reduced to yield 3-amino-2-carboxamidoimidazo[1,2-a]pyridine derivatives, which in turn were treated with nitrous acid to furnish 1-oxo-2-substituted pyrido(1′,2′:1,2)imidazo[5,4-d]-1,2,3-triazines.
Original languageAmerican English
Pages (from-to)91-94
Number of pages81
JournalJournal of Heterocyclic Chemistry
StatePublished - 1 Jan 2004

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Triazines
triazine
Pyridine
Nitrous Acid
Bioactivity
Ammonia
Amines
ammonia
Derivatives
acid
Acids
pyridine
imidazo(1,2-a)pyridine
biological activity
amine
product

Cite this

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title = "A Convenient Synthesis of Novel Pyrido(1′,2′: 1,2)imidazo[5,4-d]-1,2,3-triazinones from Imidazo[1,2-a]pyridines",
abstract = "The imidazo [1,2-a]pyridine system was investigated as a synthon for the building of very attractive fused triazines, a planar, angular tri-heterocycle with potential biological activity. Thus ethyl 3-nitroimidazo[1,2-a]pyridine-2-carboxylate was treated with ammonia or with an excess of primary amines to generate the corresponding substituted nitro carboxamidoimidazopyridines. The nitro substituent in the latter products, was reduced to yield 3-amino-2-carboxamidoimidazo[1,2-a]pyridine derivatives, which in turn were treated with nitrous acid to furnish 1-oxo-2-substituted pyrido(1′,2′:1,2)imidazo[5,4-d]-1,2,3-triazines.",
author = "{Salgado Zamora}, H{\'e}ctor and Benito Rizo and Elena Campos and Rogelio Jim{\'e}nez and Alicia Reyes",
year = "2004",
month = "1",
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journal = "Journal of Heterocyclic Chemistry",
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A Convenient Synthesis of Novel Pyrido(1′,2′: 1,2)imidazo[5,4-d]-1,2,3-triazinones from Imidazo[1,2-a]pyridines. / Salgado Zamora, Héctor; Rizo, Benito; Campos, Elena; Jiménez, Rogelio; Reyes, Alicia.

In: Journal of Heterocyclic Chemistry, 01.01.2004, p. 91-94.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - A Convenient Synthesis of Novel Pyrido(1′,2′: 1,2)imidazo[5,4-d]-1,2,3-triazinones from Imidazo[1,2-a]pyridines

AU - Salgado Zamora, Héctor

AU - Rizo, Benito

AU - Campos, Elena

AU - Jiménez, Rogelio

AU - Reyes, Alicia

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