A COL2A1 gene polymorphism is related with advanced stages of osteoarthritis of the knee in Mexican Mestizo population

Arturo Gálvez-Rosas, Celia González-Huerta, Verónica Marusa Borgonio-Cuadra, Carolina Duarte-Salazár, Lorena Lara-Alvarado, María De Los Ángeles Soria-Bastida, Socorro Cortés-González, Eva Ramón-Gallegos, Antonio Miranda-Duarte

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Abstract

Primary osteoarthritis (OA) is a multifactorial disease with several genetics factors involved. The COL2A1 gene is of particular interest because it encodes for the most abundant protein in articular cartilage. The aim was to evaluate the association of COL2A1 gene polymorphism with OA of the knee in Mexican Mestizo patients. A case-control study was conducted; cases comprised patients with a radiologic scoring ≥ 2 and controls with a radiologic scoring <2. DNA was extracted from a peripheral blood sample, the polymorphic site of the COL2A1 gene was submitted to polymerase chain reaction (PCR), and the products were digested using PvuII restriction enzyme. For statistical analysis, a non-conditional logistic regression was developed. There were no associations among alleles in the overall sample, nevertheless, a significant association was found with p (Pp/pp) allele and OA of the knee grade 4 [odds ratio (OR), 95% confidence interval (CI 95%) 4.1 (1.2-14.6)] adjusted by gender, age, and body mass index (BMI). These results suggest an association of a COL2A1 gene polymorphism with advanced stages of OA of the knee in Mexican Mestizo population. © 2009 Springer-Verlag.
Original languageAmerican English
Pages (from-to)1035-1039
Number of pages931
JournalRheumatology International
DOIs
StatePublished - 1 Jun 2010

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    Gálvez-Rosas, A., González-Huerta, C., Borgonio-Cuadra, V. M., Duarte-Salazár, C., Lara-Alvarado, L., De Los Ángeles Soria-Bastida, M., Cortés-González, S., Ramón-Gallegos, E., & Miranda-Duarte, A. (2010). A COL2A1 gene polymorphism is related with advanced stages of osteoarthritis of the knee in Mexican Mestizo population. Rheumatology International, 1035-1039. https://doi.org/10.1007/s00296-009-1091-4