A C-3-Selective Direct Alkylation of Coumarins by Using a Microwave-Assisted Xanthate-Based Radical Reaction

Luis D. Miranda, Estefanía Icelo-Ávila, Ángel Rentería-Gõmez, Michell Pila, Joaquín G. Marrero

Research output: Contribution to journalArticle

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Abstract

Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. A xanthate-based oxidative radical process for the direct alkylation of the coumarin ring system is presented. In the reaction, a vinylic and unactivated C-H bond of the coumarin system is replaced by an α-acyl functionality under neutral conditions. This reaction has a high reaction site selectivity, which can realize alkylation at the C-3 position. A vinylic and unactivated C-H bond of the coumarin system is replaced by an alkyl functionality trough a xanthate-based radical reaction (DLP = dilauroyl peroxide).
Original languageAmerican English
Pages (from-to)4098-4101
Number of pages3687
JournalEuropean Journal of Organic Chemistry
DOIs
StatePublished - 1 Jul 2015

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